Literature DB >> 25366414

Electronic surveillance and pharmacist intervention for vulnerable older inpatients on high-risk medication regimens.

Josh F Peterson1, Sunil Kripalani, Ioana Danciu, Debbie Harrell, Marketa Marvanova, Amanda S Mixon, Carmen Rodriguez, James S Powers.   

Abstract

OBJECTIVES: To develop and evaluate an electronic tool to assist clinical pharmacists with reviewing potentially inappropriate medications (PIMs) in hospitalized elderly adults.
DESIGN: Pilot intervention.
SETTING: Academic tertiary care hospital. PARTICIPANTS: Hospitalized adults aged 65 and older admitted to the general medicine, orthopedics, and urology services during a 3-week period in 2011 who were administered at least one medication from a list of 240 PIMs. INTERVENTION: A computerized PIMS dashboard flagged individuals with at least one administered PIM or a high calculated anticholinergic score. The dashboard also displayed 48-hour cumulative narcotic and benzodiazepine administration. Participants were ranked to reflect the estimated risk of an adverse event using logical combinations of data (e.g., use of multiple sedatives in a nonmonitored location). In a pilot implementation, a clinical pharmacist reviewed the flagged records and delivered an immediate point-of-care intervention for the treating physician. MEASUREMENTS: Clinician response to pharmacist intervention.
RESULTS: The PIMS dashboard flagged 179 of 797 individuals (22%) admitted over a 3-week period and 485 participant-medication pairs for review by the clinical pharmacist. Seventy-one participant records with 139 participant-medication pairs required additional manual review of the electronic medical record. Twenty-two participants receiving 40 inappropriate medication orders were judged to warrant an intervention, which was delivered by personal communication over the telephone or text message. Clinicians enacted 31 of 40 (78%) pharmacist recommendations.
CONCLUSION: An electronic PIM dashboard provided an efficient mechanism for clinical pharmacists to rapidly screen the medication regimens of hospitalized elderly adults and deliver a timely point-of-care intervention when indicated.
© 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

Entities:  

Keywords:  acute care; clinical informatics; geriatrics; medication safety; pharmacy intervention; vulnerable elderly

Mesh:

Year:  2014        PMID: 25366414      PMCID: PMC4337022          DOI: 10.1111/jgs.13057

Source DB:  PubMed          Journal:  J Am Geriatr Soc        ISSN: 0002-8614            Impact factor:   5.562


  31 in total

1.  Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly.

Authors:  Graziano Onder; Francesco Landi; Matteo Cesari; Giovanni Gambassi; Pierugo Carbonin; Roberto Bernabei
Journal:  Eur J Clin Pharmacol       Date:  2003-05-07       Impact factor: 2.953

2.  Anticholinergic activity of 107 medications commonly used by older adults.

Authors:  Marci L Chew; Benoit H Mulsant; Bruce G Pollock; Mark E Lehman; Andrew Greenspan; Ramy A Mahmoud; Margaret A Kirshner; Denise A Sorisio; Robert R Bies; Georges Gharabawi
Journal:  J Am Geriatr Soc       Date:  2008-05-26       Impact factor: 5.562

3.  Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients.

Authors:  Hilary Hamilton; Paul Gallagher; Cristin Ryan; Stephen Byrne; Denis O'Mahony
Journal:  Arch Intern Med       Date:  2011-06-13

Review 4.  Clinical pharmacists and inpatient medical care: a systematic review.

Authors:  Peter J Kaboli; Angela B Hoth; Brad J McClimon; Jeffrey L Schnipper
Journal:  Arch Intern Med       Date:  2006-05-08

5.  Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial.

Authors:  Allison B McCoy; Zachary L Cox; Erin B Neal; Lemuel R Waitman; Neeraja B Peterson; Gautam Bhave; Edward D Siew; Ioana Danciu; Julia B Lewis; Josh F Peterson
Journal:  Appl Clin Inform       Date:  2012-06-13       Impact factor: 2.342

6.  Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial.

Authors:  Sunil Kripalani; Christianne L Roumie; Anuj K Dalal; Courtney Cawthon; Alexandra Businger; Svetlana K Eden; Ayumi Shintani; Kelly Cunningham Sponsler; L Jeff Harris; Cecelia Theobald; Robert L Huang; Danielle Scheurer; Susan Hunt; Terry A Jacobson; Kimberly J Rask; Viola Vaccarino; Tejal K Gandhi; David W Bates; Mark V Williams; Jeffrey L Schnipper
Journal:  Ann Intern Med       Date:  2012-07-03       Impact factor: 25.391

7.  STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers' criteria.

Authors:  Paul Gallagher; Denis O'Mahony
Journal:  Age Ageing       Date:  2008-10-01       Impact factor: 10.668

8.  The anticholinergic risk scale and anticholinergic adverse effects in older persons.

Authors:  James L Rudolph; Marci J Salow; Michael C Angelini; Regina E McGlinchey
Journal:  Arch Intern Med       Date:  2008-03-10

9.  Inappropriate medication use among frail elderly inpatients.

Authors:  Joseph T Hanlon; Margaret B Artz; Carl F Pieper; Catherine I Lindblad; Richard J Sloane; Christine M Ruby; Kenneth E Schmader
Journal:  Ann Pharmacother       Date:  2004-01       Impact factor: 3.154

10.  Application of STOPP and START criteria: interrater reliability among pharmacists.

Authors:  Cristin Ryan; Denis O'Mahony; Stephen Byrne
Journal:  Ann Pharmacother       Date:  2009-07-07       Impact factor: 3.154

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  15 in total

1.  Reduction in targeted potentially inappropriate medication use in elderly inpatients: a pragmatic randomized controlled trial.

Authors:  Benoit Cossette; Jean-François Éthier; Thomas Joly-Mischlich; Josée Bergeron; Geneviève Ricard; Serge Brazeau; Mathieu Caron; Olivier Germain; Hélène Payette; Janusz Kaczorowski; Mitchell Levine
Journal:  Eur J Clin Pharmacol       Date:  2017-07-17       Impact factor: 2.953

Review 2.  Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients.

Authors:  Brendan J Ng; David G Le Couteur; Sarah N Hilmer
Journal:  Drugs Aging       Date:  2018-06       Impact factor: 3.923

3.  Potentially Inappropriate Medications and Anticholinergic Burden in Older People Attending Memory Clinics in Australia.

Authors:  Amanda J Cross; Johnson George; Michael C Woodward; David Ames; Henry Brodaty; Jenni Ilomäki; Rohan A Elliott
Journal:  Drugs Aging       Date:  2016-01       Impact factor: 3.923

4.  Systematic review of predictive risk models for adverse drug events in hospitalized patients.

Authors:  Nazanin Falconer; Michael Barras; Neil Cottrell
Journal:  Br J Clin Pharmacol       Date:  2018-02-22       Impact factor: 4.335

5.  A Pharmacist-Physician Intervention Model Using a Computerized Alert System to Reduce High-Risk Medication Use in Elderly Inpatients.

Authors:  Karolann Arvisais; Sabrina Bergeron-Wolff; Christine Bouffard; Anne-Sophie Michaud; Josée Bergeron; Louise Mallet; Serge Brazeau; Thomas Joly-Mischlich; Nora Bernier-Filion; Luc Lanthier; Geneviève Ricard; Marie-Claude Rodrigue; Benoit Cossette
Journal:  Drugs Aging       Date:  2015-08       Impact factor: 3.923

Review 6.  Using EMR-enabled computerized decision support systems to reduce prescribing of potentially inappropriate medications: a narrative review.

Authors:  Ian A Scott; Peter I Pillans; Michael Barras; Christopher Morris
Journal:  Ther Adv Drug Saf       Date:  2018-07-12

Review 7.  Interventions to improve the appropriate use of polypharmacy for older people.

Authors:  Audrey Rankin; Cathal A Cadogan; Susan M Patterson; Ngaire Kerse; Chris R Cardwell; Marie C Bradley; Cristin Ryan; Carmel Hughes
Journal:  Cochrane Database Syst Rev       Date:  2018-09-03

Review 8.  Screening for Medication Appropriateness in Older Adults.

Authors:  Andrew R Zullo; Shelly L Gray; Holly M Holmes; Zachary A Marcum
Journal:  Clin Geriatr Med       Date:  2017-10-14       Impact factor: 3.529

Review 9.  Current issues in patient safety in surgery: a review.

Authors:  Fernando J Kim; Rodrigo Donalisio da Silva; Diedra Gustafson; Leticia Nogueira; Timothy Harlin; David L Paul
Journal:  Patient Saf Surg       Date:  2015-06-05

10.  Patterns of Prescription Drug Use Before and After Fragility Fracture.

Authors:  Jeffrey C Munson; Julie P W Bynum; John-Erik Bell; Robert Cantu; Christine McDonough; Qianfei Wang; Tor D Tosteson; Anna N A Tosteson
Journal:  JAMA Intern Med       Date:  2016-10-01       Impact factor: 21.873

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