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Literature DB >> 25366235

Temperature sensitivity of two-pore (K2P) potassium channels.

Eve R Schneider¹, Evan O Anderson¹, Elena O Gracheva², Sviatoslav N Bagriantsev¹.

Abstract

At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Ion channel; K(2P); Potassium channel; TRAAK; TREK-1; TREK-2; Thermosensitivity; Thermotransduction; Two-pore

Mesh：

Substances：
Potassium Channels

Year: 2014 PMID： 25366235 PMCID： PMC4794111 DOI： 10.1016/B978-0-12-800181-3.00005-1

Source DB: PubMed Journal: Curr Top Membr ISSN： 1063-5823 Impact factor: 3.049

104 in total

1. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.

Authors: F Maingret; A J Patel; F Lesage; M Lazdunski; E Honoré
Journal: J Biol Chem Date: 1999-09-17 Impact factor: 5.157

2. TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.

Authors: Cristian Acosta; Laiche Djouhri; Roger Watkins; Carol Berry; Kirsty Bromage; Sally N Lawson
Journal: J Neurosci Date: 2014-01-22 Impact factor: 6.167

3. TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family.

Authors: H Bang; Y Kim; D Kim
Journal: J Biol Chem Date: 2000-06-09 Impact factor: 5.157

4. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.

Authors: Bertrand Coste; Jayanti Mathur; Manuela Schmidt; Taryn J Earley; Sanjeev Ranade; Matt J Petrus; Adrienne E Dubin; Ardem Patapoutian
Journal: Science Date: 2010-09-02 Impact factor: 47.728

5. Optical probing of a dynamic membrane interaction that regulates the TREK1 channel.

Authors: Guillaume Sandoz; Sarah C Bell; Ehud Y Isacoff
Journal: Proc Natl Acad Sci U S A Date: 2011-01-24 Impact factor: 11.205

6. Involvement of TREK-1 activity in astrocyte function and neuroprotection under simulated ischemia conditions.

Authors: Xiao Wu; Yang Liu; Xiaojing Chen; Qian Sun; Ronghua Tang; Wei Wang; Zhiyuan Yu; Minjie Xie
Journal: J Mol Neurosci Date: 2012-08-16 Impact factor: 3.444

7. PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.

Authors: Coeli M B Lopes; Tibor Rohács; Gábor Czirják; Tamás Balla; Péter Enyedi; Diomedes E Logothetis
Journal: J Physiol Date: 2005-01-27 Impact factor: 5.182

8. Neuroprotective role of the TREK-1 channel in decompression sickness.

Authors: Nicolas Vallee; Cédric Meckler; Jean-Jacques Risso; Jean-Eric Blatteau
Journal: J Appl Physiol (1985) Date: 2012-02-09

9. Regulation of Monocyte Chemotactic Protein-1 secretion by the Two-Pore-Domain Potassium (K2P) channel TREK-1 in human alveolar epithelial cells.

Authors: Andreas Schwingshackl; Bin Teng; Manik Ghosh; Christopher M Waters
Journal: Am J Transl Res Date: 2013-08-15 Impact factor: 4.060

10. The core domain as the force sensor of the yeast mechanosensitive TRP channel.

Authors: Zhenwei Su; Andriy Anishkin; Ching Kung; Yoshiro Saimi
Journal: J Gen Physiol Date: 2011-12 Impact factor: 4.086

19 in total

1. Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.

Authors: Cristina Arrigoni; Ahmed Rohaim; David Shaya; Felix Findeisen; Richard A Stein; Shailika Reddy Nurva; Smriti Mishra; Hassane S Mchaourab; Daniel L Minor
Journal: Cell Date: 2016-02-25 Impact factor: 41.582

2. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels.

Authors: Willem J Laursen; Eve R Schneider; Dana K Merriman; Sviatoslav N Bagriantsev; Elena O Gracheva
Journal: Proc Natl Acad Sci U S A Date: 2016-09-16 Impact factor: 11.205

Review 3. The Structural and Functional Diversity of Intrinsically Disordered Regions in Transmembrane Proteins.

Authors: Rajeswari Appadurai; Vladimir N Uversky; Anand Srivastava
Journal: J Membr Biol Date: 2019-05-28 Impact factor: 1.843

4. Reduction of spike generation frequency by cooling in brain slices from rats and from patients with epilepsy.

Authors: Sadahiro Nomura; Hiroyuki Kida; Yuya Hirayama; Hirochika Imoto; Takao Inoue; Hiroshi Moriyama; Dai Mitsushima; Michiyasu Suzuki
Journal: J Cereb Blood Flow Metab Date: 2018-08-17 Impact factor: 6.200

5. Ultrasound Elicits Behavioral Responses through Mechanical Effects on Neurons and Ion Channels in a Simple Nervous System.

Authors: Jan Kubanek; Poojan Shukla; Alakananda Das; Stephen A Baccus; Miriam B Goodman
Journal: J Neurosci Date: 2018-02-20 Impact factor: 6.167

6. Sodium Channel Na_v1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.

Authors: Amanda H Klein; Alina Vyshnevska; Timothy V Hartke; Roberto De Col; Joseph L Mankowski; Brian Turnquist; Frank Bosmans; Peter W Reeh; Martin Schmelz; Richard W Carr; Matthias Ringkamp
Journal: J Neurosci Date: 2017-04-27 Impact factor: 6.167