Siavash Fazelian1, Mostafa Hoseini2, Nazli Namazi3, Javad Heshmati1, Mehdi Sepidar Kish2, Maryam Mirfatahi4, Ahmad Saedi Some Olia1. 1. Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Biostatistics, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran. 3. Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. 4. Faculty of Food and Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
PURPOSE: The aim of present study was to determine effects of L-Arginine supplementation on antioxidant status and body composition in obese patients with prediabetes. METHODS: A double-blind randomized control trial was performed on 46 (24 men, 22 women) obese patients with prediabetes. They were divided randomly into two groups. Patients in intervention (n = 23) and control group (n=23) received 3 gr/day L-arginine and placebo, respectively for 8 weeks. Anthropometric indices, dietary intake and biochemical measurements ((serum total antioxidant capacity (TAC), Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD)) were performed at the baseline and after 8-week intervention. RESULTS: The mean age and BMI of participants were 44.29±8.65 years old and 28.14±1.35 kg/m(2), respectively. At the end of study, in both intervention and control group, percentage of carbohydrate decreased and %fat intake increased compared to the baseline (P<0.05). After adjusting for dietary intake, no significant difference was observed in Fat Mass (FM) and Fat Free Mass (FFM) between two groups (P>0.05). Among measured biochemical factors, only serum TAC level showed significant differences at the end of study in the intervention group compared to the control group (pv<0.01). CONCLUSION: 3gr/day L-Arginine supplementation increased TAC level in obese patients with prediabetes.
RCT Entities:
PURPOSE: The aim of present study was to determine effects of L-Arginine supplementation on antioxidant status and body composition in obesepatients with prediabetes. METHODS: A double-blind randomized control trial was performed on 46 (24 men, 22 women) obesepatients with prediabetes. They were divided randomly into two groups. Patients in intervention (n = 23) and control group (n=23) received 3 gr/day L-arginine and placebo, respectively for 8 weeks. Anthropometric indices, dietary intake and biochemical measurements ((serum total antioxidant capacity (TAC), Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD)) were performed at the baseline and after 8-week intervention. RESULTS: The mean age and BMI of participants were 44.29±8.65 years old and 28.14±1.35 kg/m(2), respectively. At the end of study, in both intervention and control group, percentage of carbohydrate decreased and %fat intake increased compared to the baseline (P<0.05). After adjusting for dietary intake, no significant difference was observed in Fat Mass (FM) and Fat Free Mass (FFM) between two groups (P>0.05). Among measured biochemical factors, only serum TAC level showed significant differences at the end of study in the intervention group compared to the control group (pv<0.01). CONCLUSION: 3gr/day L-Arginine supplementation increased TAC level in obesepatients with prediabetes.
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