Literature DB >> 25363160

A reduction and pH dual-sensitive polymeric vector for long-circulating and tumor-targeted siRNA delivery.

Jingguo Li1, Xingsu Yu, Yong Wang, Yuanyuan Yuan, Hong Xiao, Du Cheng, Xintao Shuai.   

Abstract

A novel reduction and pH dual-sensitive nonviral vector for long-circulating and tumor-targeted siRNA delivery is described. The nanomedicine is negatively charged at neutral pH of bloodstream whereas it is positively charged at lower pH of tumor tissue (ca. 6.8). Interlayer crosslinking with disulfide bonds stabilizes the nanomedicine during blood circulation and allows quick intracellular siRNA release after endocytosis.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cancer treatment; charge reversal; micelles; reducible; siRNA delivery

Mesh：

Substances：

Year:  2014        PMID： 25363160     DOI： 10.1002/adma.201403877

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  26 in total

1.  Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy.

Authors:  Xiaoding Xu; Jun Wu; Shuaishuai Liu; Phei Er Saw; Wei Tao; Yujing Li; Lisa Krygsman; Srinivasan Yegnasubramanian; Angelo M De Marzo; Jinjun Shi; Charles J Bieberich; Omid C Farokhzad
Journal:  Small       Date:  2018-09-17       Impact factor: 13.281

Review 2.  Particle-based technologies for osteoarthritis detection and therapy.

Authors:  Taylor E Kavanaugh; Thomas A Werfel; Hongsik Cho; Karen A Hasty; Craig L Duvall
Journal:  Drug Deliv Transl Res       Date:  2016-04       Impact factor: 4.617

3.  Efficient tuning of siRNA dose response by combining mixed polymer nanocarriers with simple kinetic modeling.

Authors:  Chad T Greco; Victoria G Muir; Thomas H Epps; Millicent O Sullivan
Journal:  Acta Biomater       Date:  2017-01-04       Impact factor: 8.947

Review 4.  Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery.

Authors:  Byungji Kim; Ji-Ho Park; Michael J Sailor
Journal:  Adv Mater       Date:  2019-09-30       Impact factor: 30.849

5.  Shape Control in Engineering of Polymeric Nanoparticles for Therapeutic Delivery.

Authors:  John-Michael Williford; Jose Luis Santos; Rishab Shyam; Hai-Quan Mao
Journal:  Biomater Sci       Date:  2015-07       Impact factor: 6.843

Review 6.  Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers.

Authors:  Jian-Ping Liu; Ting-Ting Wang; Dang-Ge Wang; An-Jie Dong; Ya-Ping Li; Hai-Jun Yu
Journal:  Acta Pharmacol Sin       Date:  2016-08-29       Impact factor: 6.150

7.  Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.

Authors:  Sheng Wang; Peng Huang; Xiaoyuan Chen
Journal:  Adv Mater       Date:  2016-06-03       Impact factor: 30.849

8.  Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

Authors:  Jinmyoung Joo; Ester J Kwon; Jinyoung Kang; Matthew Skalak; Emily J Anglin; Aman P Mann; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor
Journal:  Nanoscale Horiz       Date:  2016-06-14       Impact factor: 10.989

9.  A DOX-loaded polymer micelle for effectively inhibiting cancer cells.

Authors:  Huayang Feng; Dandan Chu; Zhanrong Li; Zhihua Guo; Lin Jin; Bingbing Fan; Junjie Zhang; Jingguo Li
Journal:  RSC Adv       Date:  2018-07-19       Impact factor: 4.036

Review 10.  Recent Advances in Stimulus-Responsive Nanocarriers for Gene Therapy.

Authors:  Cheng Yu; Long Li; Pei Hu; Yan Yang; Wei Wei; Xin Deng; Lu Wang; Franklin R Tay; Jingzhi Ma
Journal:  Adv Sci (Weinh)       Date:  2021-05-16       Impact factor: 16.806
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