Riya Pal Chaudhuri1, Ujjwal Neogi, Shwetha D Rao, Anita Shet. 1. Departments *Clinical Virology, #Hematology Research Unit, Microbiology and Department of Pediatrics, St. John's Medical College Hospital, Bangalore, India. Correspondence to: Dr Anita Shet, Department of Pediatrics, St. Johns Medical College Hospital, Bangalore 560 034, India. anitashet@stjohns.in.
Abstract
OBJECTIVE: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India. METHODS: ART-naïve children were identified and selected host factors including CCR5-∆32, SDF1-3'A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits. RESULTS: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-∆32 deletion, SDF1-3'A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3'A and/or CCR5-59029G. CONCLUSIONS: There is an association between host genetic factors and slow disease progression in this population.
OBJECTIVE: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India. METHODS: ART-naïve children were identified and selected host factors including CCR5-∆32, SDF1-3'A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits. RESULTS: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-∆32 deletion, SDF1-3'A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3'A and/or CCR5-59029G. CONCLUSIONS: There is an association between host genetic factors and slow disease progression in this population.
Authors: Anurag Rathore; Animesh Chatterjee; P Sivarama; Naohiko Yamamoto; Pradeep K Singhal; Tapan N Dhole Journal: AIDS Res Hum Retroviruses Date: 2009-11 Impact factor: 2.205
Authors: John P A Ioannidis; Despina G Contopoulos-Ioannidis; Philip S Rosenberg; James J Goedert; Anita De Rossi; Teresa Espanol; Lisa Frenkel; Marie-Jeanne Mayaux; Marie-Louise Newell; Savita G Pahwa; Christine Rousseau; Gabriella Scarlatti; Shizuko Sei; Luisa Sen; Thomas R O'Brien Journal: AIDS Date: 2003-07-25 Impact factor: 4.177
Authors: M E Feeney; Y Tang; K A Roosevelt; A J Leslie; K McIntosh; N Karthas; B D Walker; P J R Goulder Journal: J Virol Date: 2004-08 Impact factor: 5.103
Authors: M Magierowska; I Theodorou; P Debré; F Sanson; B Autran; Y Rivière; D Charron; D Costagliola Journal: Blood Date: 1999-02-01 Impact factor: 22.113
Authors: Paul A Goepfert; Wendy Lumm; Paul Farmer; Philippa Matthews; Andrew Prendergast; Jonathan M Carlson; Cynthia A Derdeyn; Jianming Tang; Richard A Kaslow; Anju Bansal; Karina Yusim; David Heckerman; Joseph Mulenga; Susan Allen; Philip J R Goulder; Eric Hunter Journal: J Exp Med Date: 2008-04-21 Impact factor: 14.307