Literature DB >> 2536173

Voltage-gated channels formed in lipid bilayers by a positively charged segment of the Na-channel polypeptide.

M T Tosteson1, D S Auld, D C Tosteson.   

Abstract

The Na-channel polypeptide is responsible for the voltage-gated and time-dependent ionic permeability changes that give rise to the action potential in the membranes of nerve cells. We have synthesized a 22-amino acid peptide with a sequence identical to that of the segment named S4, repeat IV of the primary structure of the Na channel. We have found that this peptide induces a voltage- and time-dependent conductance in bilayers formed by a mixture of phosphatidyl-ethanolamine and phosphatidylserine. This conductance is activated when the cis side is made positive, with an apparent gating charge of 3. The results are consistent with the idea that this segment plays a role in determining the voltage sensitivity of the Na channel.

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Year:  1989        PMID： 2536173      PMCID： PMC286543          DOI： 10.1073/pnas.86.2.707

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

1.  The structure of the voltage-sensitive sodium channel. Inferences derived from computer-aided analysis of the Electrophorus electricus channel primary structure.

Authors:  R E Greenblatt; Y Blatt; M Montal
Journal:  FEBS Lett       Date:  1985-12-02       Impact factor: 4.124

2.  Molecular model of the action potential sodium channel.

Authors:  H R Guy; P Seetharamulu
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

3.  The synthetic precursor specific region of pre-pro-parathyroid hormone forms ion channels in lipid bilayers.

Authors:  M T Tosteson; M P Caulfield; J J Levy; M Rosenblatt; D C Tosteson
Journal:  Biosci Rep       Date:  1988-04       Impact factor: 3.840

4.  The gramicidin pore: crystal structure of a cesium complex.

Authors:  B A Wallace; K Ravikumar
Journal:  Science       Date:  1988-07-08       Impact factor: 47.728

5.  M2 delta, a candidate for the structure lining the ionic channel of the nicotinic cholinergic receptor.

Authors:  S Oiki; W Danho; V Madison; M Montal
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

6.  Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties.

Authors:  M Montal; P Mueller
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205

7.  Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.

Authors:  M Noda; S Shimizu; T Tanabe; T Takai; T Kayano; T Ikeda; H Takahashi; H Nakayama; Y Kanaoka; N Minamino
Journal:  Nature       Date:  1984 Nov 8-14       Impact factor: 49.962

8.  The sting. Melittin forms channels in lipid bilayers.

Authors:  M T Tosteson; D C Tosteson
Journal:  Biophys J       Date:  1981-10       Impact factor: 4.033

9.  Analysis of membrane and surface protein sequences with the hydrophobic moment plot.

Authors:  D Eisenberg; E Schwarz; M Komaromy; R Wall
Journal:  J Mol Biol       Date:  1984-10-15       Impact factor: 5.469

10.  A structural model of the acetylcholine receptor channel based on partition energy and helix packing calculations.

Authors:  H R Guy
Journal:  Biophys J       Date:  1984-01       Impact factor: 4.033
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  20 in total

1.  The NB protein of influenza B virus is not necessary for virus replication in vitro.

Authors:  Masato Hatta; Yoshihiro Kawaoka
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

2.  Involvement of different S4 parts in the voltage dependency of Na channel gating.

Authors:  Z Kra-Oz; G Spira; Y Palti; H Meiri
Journal:  J Membr Biol       Date:  1992-08       Impact factor: 1.843

3.  Depolarization exposes the voltage sensor of the sodium channels to the extracellular region.

Authors:  M Sammar; G Spira; H Meiri
Journal:  J Membr Biol       Date:  1992-01       Impact factor: 1.843

4.  Structural and biophysical properties of a synthetic channel-forming peptide: designing a clinically relevant anion selective pore.

Authors:  U Bukovnik; J Gao; G A Cook; L P Shank; M B Seabra; B D Schultz; T Iwamoto; J Chen; J M Tomich
Journal:  Biochim Biophys Acta       Date:  2011-07-31

5.  Primary structure of peptides and ion channels. Role of amino acid side chains in voltage gating of melittin channels.

Authors:  M T Tosteson; O Alvarez; W Hubbell; R M Bieganski; C Attenbach; L H Caporales; J J Levy; R F Nutt; M Rosenblatt; D C Tosteson
Journal:  Biophys J       Date:  1990-12       Impact factor: 4.033

6.  Effect of diaminopropionic acid (Dap) on the biophysical properties of a modified synthetic channel-forming peptide.

Authors:  Urska Bukovnik; Monica Sala-Rabanal; Simonne Francis; Shawnalea J Frazier; Bruce D Schultz; Colin G Nichols; John M Tomich
Journal:  Mol Pharm       Date:  2013-09-23       Impact factor: 4.939

7.  Ion channels induced in lipid bilayers by subvirion particles of the nonenveloped mammalian reoviruses.

Authors:  M T Tosteson; M L Nibert; B N Fields
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

8.  Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication.

Authors:  F J van Kuppeveld; J M Galama; J Zoll; P J van den Hurk; W J Melchers
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

9.  A synthetic S6 segment derived from KvAP channel self-assembles, permeabilizes lipid vesicles, and exhibits ion channel activity in bilayer lipid membrane.

Authors:  Richa Verma; Chetan Malik; Sarfuddin Azmi; Saurabh Srivastava; Subhendu Ghosh; Jimut Kanti Ghosh
Journal:  J Biol Chem       Date:  2011-05-18       Impact factor: 5.157

10.  Gating in iodate-modified single cardiac Na+ channels.

Authors:  M Kohlhardt; H Fichtner; U Fröbe
Journal:  J Membr Biol       Date:  1989-11       Impact factor: 1.843
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