Literature DB >> 25360339

"Tiers of delay": warfarin, hip fractures, and target-driven care.

W G P Eardley1, K E Macleod1, H Freeman1, A Tate1.   

Abstract

Anticoagulation reversal is a common cause of operative delay. We sought to establish for the first time the impact this has on best practice tariff (BPT) for patients with hip fracture admitted on warfarin. All patients with hip fracture treated operatively over a 32-month period were reviewed. Basic demographics, time to theater, length of stay, and mortality were recorded for all patients. Independent samples t-tests were used to identify statistically significant differences between patients on warfarin and those not taking the drug. A total of 83 patients were admitted anticoagulated with a mean international normalized ratio of 2.65 and a median time to theater of 49.7 hours. Of these patients, 79% breached BPT, incurring significant financial loss. In the control group, 908 patients took a median 24.5 hours, a 28% breach of BPT (P < .01). Length of stay, Nottingham Hip Fracture Score, and predicted 30-day mortality were similar for both the groups. As well as affecting clinical outcome following hip fracture, delay due to anticoagulation causes considerable loss of BPT. Potential loss of revenue due to delays over the study period was £80 000, inspiring the establishment of an "early trigger" anticoagulation protocol. Although it is accepted that there are limitations to this work, it should raise awareness of the real impact of warfarin on patients with hip fracture both in terms of outcome and for the first time, loss of potential revenue.

Entities:  

Keywords:  basic research; fragility fractures; geriatric trauma; systems of care; trauma surgery

Year:  2014        PMID: 25360339      PMCID: PMC4212424          DOI: 10.1177/2151458514532469

Source DB:  PubMed          Journal:  Geriatr Orthop Surg Rehabil        ISSN: 2151-4585


  27 in total

1.  The Best Practice Tariff helps improve management of neck of femur fractures: a completed audit loop.

Authors:  S K Khan; A Weusten; S Bonczek; A Tate; A Port
Journal:  Br J Hosp Med (Lond)       Date:  2013-11       Impact factor: 0.825

2.  Efficacy of warfarin reversal in orthopedic trauma surgery patients.

Authors:  Pritam Tharmarajah; Jane Pusey; David Keeling; Keith Willett
Journal:  J Orthop Trauma       Date:  2007-01       Impact factor: 2.512

3.  Use of warfarin is associated with delay in surgery for hip fracture in older patients.

Authors:  Anette Hylen Ranhoff; Mette Irene Martinsen; Kristin Holvik; Ludvig Fjeld Solheim
Journal:  Hosp Pract (1995)       Date:  2011-02

4.  Anticoagulation management in hip fracture patients on warfarin.

Authors:  Mamun Al-Rashid; Martyn J Parker
Journal:  Injury       Date:  2005-11       Impact factor: 2.586

Review 5.  How I treat anticoagulated patients undergoing an elective procedure or surgery.

Authors:  Alex C Spyropoulos; James D Douketis
Journal:  Blood       Date:  2012-08-28       Impact factor: 22.113

6.  Early mortality after hip fracture: is delay before surgery important?

Authors:  Christopher G Moran; Russell T Wenn; Manoj Sikand; Andrew M Taylor
Journal:  J Bone Joint Surg Am       Date:  2005-03       Impact factor: 5.284

7.  Implementing the National Hip Fracture Database: An audit of care.

Authors:  Nirav K Patel; Khaled M Sarraf; Sarah Joseph; Chooi Lee; Fiona R Middleton
Journal:  Injury       Date:  2013-05-13       Impact factor: 2.586

Review 8.  Periprocedural heparin bridging in patients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding and thromboembolic rates.

Authors:  Deborah Siegal; Jovana Yudin; Scott Kaatz; James D Douketis; Wendy Lim; Alex C Spyropoulos
Journal:  Circulation       Date:  2012-08-21       Impact factor: 29.690

9.  Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery.

Authors:  M J Maxwell; C G Moran; I K Moppett
Journal:  Br J Anaesth       Date:  2008-08-21       Impact factor: 9.166

10.  Management of warfarin anticoagulation in patients with fractured neck of femur.

Authors:  Feras Ashouri; Wissam Al-Jundi; Akash Patel; Jitendra Mangwani
Journal:  ISRN Hematol       Date:  2011-02-24
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  15 in total

1.  Do cancer patients undergoing surgery for a non-neoplastic related fragility hip fracture have worse outcomes? A retrospective study.

Authors:  Tal Frenkel Rutenberg; Maria Vitenberg; Efrat Daglan; Juan Pretell-Mazzini; Shai Shemesh
Journal:  Arch Orthop Trauma Surg       Date:  2021-06-07       Impact factor: 3.067

Review 2.  The Perioperative Management of Antiplatelet and Anticoagulant Drugs in Hip Fractures: Do the Surgery as Early as Possible.

Authors:  Mohammad Ali Ghasemi; Ehsan Ghadimi; Ahmad Shamabadi; Sm Javad Mortazavi
Journal:  Arch Bone Jt Surg       Date:  2022-06

3.  "Early Trigger" Intravenous Vitamin K: Optimizing Target-Driven Care in Warfarinised Patients With Hip Fracture.

Authors:  Marina Diament; Kirsty MacLeod; Jonathan O'Hare; Anne Tate; Will Eardley
Journal:  Geriatr Orthop Surg Rehabil       Date:  2015-12

4.  Current Practices Regarding Perioperative Management of Patients With Fracture on Antiplatelet Therapy: A Survey of Orthopedic Surgeons.

Authors:  Christian A Pean; Abraham Goch; Anthony Christiano; Sanjit Konda; Kenneth Egol
Journal:  Geriatr Orthop Surg Rehabil       Date:  2015-12

5.  Do Patients Taking Warfarin Experience Delays to Theatre, Longer Hospital Stay, and Poorer Survival After Hip Fracture?

Authors:  John E Lawrence; Daniel M Fountain; Duncan J Cundall-Curry; Andrew D Carrothers
Journal:  Clin Orthop Relat Res       Date:  2016-09-01       Impact factor: 4.176

6.  Anticoagulation therapy and proximal femoral fracture treatment: An update.

Authors:  Ioannis Ktistakis; Vasileios Giannoudis; Peter V Giannoudis
Journal:  EFORT Open Rev       Date:  2017-03-13

7.  Does Use of Oral Anticoagulants at the Time of Admission Affect Outcomes Following Hip Fracture.

Authors:  Ariana Lott; Jack Haglin; Rebekah Belayneh; Sanjit R Konda; Philipp Leucht; Kenneth A Egol
Journal:  Geriatr Orthop Surg Rehabil       Date:  2018-03-29

8.  The Fascia Iliaca Block as the Primary Intraoperative Anesthesia for Hip Fracture Surgery: A Preliminary Study.

Authors:  Joseph J Ruzbarsky; Elizabeth B Gausden; Elan M Goldwyn; Isaac P Lowenwirt; Vitaly Kotlyar
Journal:  HSS J       Date:  2017-10-31

9.  A Stab in the Dark? Point-of-Care Testing in the Population With Hip Fracture.

Authors:  Claire Dawkins; Kate Atkinson; Anne Tate; W G P Eardley
Journal:  Geriatr Orthop Surg Rehabil       Date:  2015-09

10.  Use of Anticoagulants Remains a Significant Threat to Timely Hip Fracture Surgery.

Authors:  Razvan Taranu; Chelsea Redclift; Patrick Williams; Marina Diament; Anne Tate; Jamie Maddox; Faye Wilson; Will Eardley
Journal:  Geriatr Orthop Surg Rehabil       Date:  2018-03-22
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