Literature DB >> 2535912

A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease.

S P Staal1, R Ambinder, W E Beschorner, G S Hayward, R Mann.   

Abstract

A total of 151 unselected malignant and nonmalignant lymphoid tissue samples were surveyed by Southern blotting for the presence of Epstein-Barr virus (EBV) DNA. Eight of 28 Hodgkin's disease (HD) samples (29%) had detectable EBV DNA. Both nodular sclerosis and mixed cellularity histologic results were positive. The tumor type with the next highest frequency, 8%, was diffuse large cell lymphoma. The presence of EBV DNA in some HD biopsies suggests that EBV may be a factor in the pathogenesis of this disease. Alternatively, its presence may be secondary to the immune deficiency characteristic of HD. The clonal B-lymphocyte expansions reported in some cases of HD may result from EBV infection.

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Year:  1989        PMID： 2535912     DOI： 10.1093/ajcp/91.1.1

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  41 in total

Review 1.  Gammaherpesviruses and "Hit-and-Run" oncogenesis.

Authors:  R F Ambinder
Journal:  Am J Pathol       Date:  2000-01       Impact factor: 4.307

2.  The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.

Authors:  R Longnecker; C L Miller; X Q Miao; A Marchini; E Kieff
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

3.  An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases.

Authors:  A L Burkhardt; J B Bolen; E Kieff; R Longnecker
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

4.  Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study.

Authors:  L M Weiss; Y Y Chen; X F Liu; D Shibata
Journal:  Am J Pathol       Date:  1991-12       Impact factor: 4.307

5.  Epstein-Barr viral genome in lymph nodes from patients with Hodgkin's disease may not be specific to Reed-Sternberg cells.

Authors:  A Masih; D Weisenburger; M Duggan; J Armitage; R Bashir; D Mitchell; R Wickert; D T Purtilo
Journal:  Am J Pathol       Date:  1991-07       Impact factor: 4.307

6.  Human herpesvirus 6 and Epstein-Barr virus in Hodgkin's disease: a controlled study by polymerase chain reaction and in situ hybridization.

Authors:  G Valente; P Secchiero; P Lusso; M C Abete; C Jemma; G Reato; S Kerim; R C Gallo; G Palestro
Journal:  Am J Pathol       Date:  1996-11       Impact factor: 4.307

7.  Absence of HLA class I expression by Reed-Sternberg cells.

Authors:  S Poppema; L Visser
Journal:  Am J Pathol       Date:  1994-07       Impact factor: 4.307

8.  The detection of Epstein-Barr virus in hairy cell leukemia cells by in situ hybridization.

Authors:  B C Wolf; A W Martin; R S Neiman; A J Janckila; L T Yam; A Caracansi; B A Leav; R Winpenny; D S Schultz; H J Wolfe
Journal:  Am J Pathol       Date:  1990-03       Impact factor: 4.307

9.  Detection of Epstein-Barr virus genomes in Hodgkin's disease: relation to age.

Authors:  R F Jarrett; A Gallagher; D B Jones; F E Alexander; A S Krajewski; A Kelsey; J Adams; B Angus; S Gledhill; D H Wright
Journal:  J Clin Pathol       Date:  1991-10       Impact factor: 3.411

10.  Possible roles of Epstein-Barr virus in Castleman disease.

Authors:  Chih-Hao Chen; Hung-Chang Liu; Tzu-Ti Hung; Tsang-Pai Liu
Journal:  J Cardiothorac Surg       Date:  2009-07-09       Impact factor: 1.637
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