Literature DB >> 25352099

SPRTN is a new player in an old story.

Kevin Hiom1.   

Abstract

A new study identifies rare mutations in SPRTN that cause a novel progeroid syndrome. The results point to an unexpected function of SPRTN and bring insight to the mechanisms that link premature aging and cancer.

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Year:  2014        PMID： 25352099     DOI： 10.1038/ng.3125

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  7 in total

Review 1.  DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.

Authors:  P Mohaghegh; I D Hickson
Journal:  Hum Mol Genet       Date:  2001-04       Impact factor: 6.150

2.  Genome instability in progeria: when repair gets old.

Authors:  Tom Misteli; Paola Scaffidi
Journal:  Nat Med       Date:  2005-07       Impact factor: 53.440

3.  A DNA-dependent protease involved in DNA-protein crosslink repair.

Authors:  Julian Stingele; Michael S Schwarz; Nicolas Bloemeke; Peter G Wolf; Stefan Jentsch
Journal:  Cell       Date:  2014-07-03       Impact factor: 41.582

4.  DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks.

Authors:  Anna Mosbech; Ian Gibbs-Seymour; Konstantinos Kagias; Tina Thorslund; Petra Beli; Lou Povlsen; Sofie Vincents Nielsen; Stine Smedegaard; Garry Sedgwick; Claudia Lukas; Rasmus Hartmann-Petersen; Jiri Lukas; Chunaram Choudhary; Roger Pocock; Simon Bekker-Jensen; Niels Mailand
Journal:  Nat Struct Mol Biol       Date:  2012-10-07       Impact factor: 15.369

5.  DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage.

Authors:  Emily J Davis; Christophe Lachaud; Paul Appleton; Thomas J Macartney; Inke Näthke; John Rouse
Journal:  Nat Struct Mol Biol       Date:  2012-10-07       Impact factor: 15.369

6.  Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.

Authors:  Davor Lessel; Bruno Vaz; Swagata Halder; Paul J Lockhart; Ivana Marinovic-Terzic; Jaime Lopez-Mosqueda; Melanie Philipp; Joe C H Sim; Katherine R Smith; Judith Oehler; Elisa Cabrera; Raimundo Freire; Kate Pope; Amsha Nahid; Fiona Norris; Richard J Leventer; Martin B Delatycki; Gotthold Barbi; Simon von Ameln; Josef Högel; Marina Degoricija; Regina Fertig; Martin D Burkhalter; Kay Hofmann; Holger Thiele; Janine Altmüller; Gudrun Nürnberg; Peter Nürnberg; Melanie Bahlo; George M Martin; Cora M Aalfs; Junko Oshima; Janos Terzic; David J Amor; Ivan Dikic; Kristijan Ramadan; Christian Kubisch
Journal:  Nat Genet       Date:  2014-09-28       Impact factor: 38.330

7.  Regulation of error-prone translesion synthesis by Spartan/C1orf124.

Authors:  Myoung Shin Kim; Yuka Machida; Ajay A Vashisht; James A Wohlschlegel; Yuan-Ping Pang; Yuichi J Machida
Journal:  Nucleic Acids Res       Date:  2012-12-18       Impact factor: 16.971
  7 in total
  3 in total

Review 1.  Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.

Authors:  Kristijan Ramadan; Swagata Halder; Katherine Wiseman; Bruno Vaz
Journal:  Chromosoma       Date:  2016-04-18       Impact factor: 4.316

2.  MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach.

Authors:  Léo Pio-Lopez; Alberto Valdeolivas; Laurent Tichit; Élisabeth Remy; Anaïs Baudot
Journal:  Sci Rep       Date:  2021-04-22       Impact factor: 4.379

Review 3.  Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes.

Authors:  Gabriel Lidzbarsky; Danielle Gutman; Huda Adwan Shekhidem; Lital Sharvit; Gil Atzmon
Journal:  Front Med (Lausanne)       Date:  2018-04-17
  3 in total

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