| Literature DB >> 25352025 |
Wei Jiang1, Feng Yao, Jing He, Bihong Lv, Wentao Fang, Weidong Zhu, Guangming He, Jianzhong Chen, Jianming He.
Abstract
VGLL4, a member of the Vestigial-like (VGLL) proteins, has been reported to be dysregulated in several cancer types. However, its function in esophageal squamous cell carcinoma (ESCC) remains poorly understood. Here, it was found that the expression level of VGLL4 was decreased in ESCC tissues. Moreover, forced expression of VGLL4 in ESCC cells inhibited cell growth and migration, while knockdown of VGLL4 expression promoted the tumorigenecity of ESCC cells. Mechanistically, VGLL4 regulated the growth and motility of ESCC cells through downregulating the expression of connective tissue growth factor (CTGF), a known oncogene in the progression of ESCC. Taken together, our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC.Entities:
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Year: 2014 PMID： 25352025 DOI： 10.1007/s13277-014-2701-7
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283