Literature DB >> 18579750

TEAD mediates YAP-dependent gene induction and growth control.

Bin Zhao1, Xin Ye, Jindan Yu, Li Li, Weiquan Li, Siming Li, Jianjun Yu, Jiandie D Lin, Cun-Yu Wang, Arul M Chinnaiyan, Zhi-Chun Lai, Kun-Liang Guan.   

Abstract

The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

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Year:  2008        PMID： 18579750      PMCID： PMC2492741          DOI： 10.1101/gad.1664408

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  35 in total

1.  A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.

Authors:  R Yagi; L F Chen; K Shigesada; Y Murakami; Y Ito
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

Review 2.  From cell structure to transcription: Hippo forges a new path.

Authors:  Bruce A Edgar
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

Review 3.  Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin.

Authors:  Andrea I McClatchey; Marco Giovannini
Journal:  Genes Dev       Date:  2005-10-01       Impact factor: 11.361

4.  Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors.

Authors:  A I McClatchey; I Saotome; K Mercer; D Crowley; J F Gusella; R T Bronson; T Jacks
Journal:  Genes Dev       Date:  1998-04-15       Impact factor: 11.361

5.  The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.

Authors:  Jianbin Huang; Shian Wu; Jose Barrera; Krista Matthews; Duojia Pan
Journal:  Cell       Date:  2005-08-12       Impact factor: 41.582

6.  A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

Authors:  Jason Moffat; Dorre A Grueneberg; Xiaoping Yang; So Young Kim; Angela M Kloepfer; Gregory Hinkle; Bruno Piqani; Thomas M Eisenhaure; Biao Luo; Jennifer K Grenier; Anne E Carpenter; Shi Yin Foo; Sheila A Stewart; Brent R Stockwell; Nir Hacohen; William C Hahn; Eric S Lander; David M Sabatini; David E Root
Journal:  Cell       Date:  2006-03-24       Impact factor: 41.582

7.  Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.

Authors:  Zhi-Chun Lai; Xiaomu Wei; Takeshi Shimizu; Edward Ramos; Margaret Rohrbaugh; Nikolas Nikolaidis; Li-Lun Ho; Ying Li
Journal:  Cell       Date:  2005-03-11       Impact factor: 41.582

8.  Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Authors:  Aravind Subramanian; Pablo Tamayo; Vamsi K Mootha; Sayan Mukherjee; Benjamin L Ebert; Michael A Gillette; Amanda Paulovich; Scott L Pomeroy; Todd R Golub; Eric S Lander; Jill P Mesirov
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-30       Impact factor: 11.205

9.  Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis.

Authors:  Nadja Dornhöfer; Suzanne Spong; Kevin Bennewith; Ali Salim; Stephen Klaus; Neeraja Kambham; Carol Wong; Fiona Kaper; Patrick Sutphin; Randall Nacamuli; Rendall Nacalumi; Michael Höckel; Quynh Le; Michael Longaker; George Yang; Albert Koong; Amato Giaccia
Journal:  Cancer Res       Date:  2006-06-01       Impact factor: 12.701

10.  A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration).

Authors:  Ragnheidur Fossdal; Fridbert Jonasson; Gudlaug T Kristjansdottir; Augustine Kong; Hreinn Stefansson; Shyamali Gosh; Jeffrey R Gulcher; Kari Stefansson
Journal:  Hum Mol Genet       Date:  2004-03-11       Impact factor: 6.150
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  1033 in total

1.  The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner.

Authors:  M Shanzer; I Ricardo-Lax; R Keshet; N Reuven; Y Shaul
Journal:  Oncogene       Date:  2014-11-03       Impact factor: 9.867

Review 2.  The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis.

Authors:  Rachel S Knipe; Andrew M Tager; James K Liao
Journal:  Pharmacol Rev       Date:  2015       Impact factor: 25.468

3.  c-Abl antagonizes the YAP oncogenic function.

Authors:  R Keshet; J Adler; I Ricardo Lax; M Shanzer; Z Porat; N Reuven; Y Shaul
Journal:  Cell Death Differ       Date:  2014-10-31       Impact factor: 15.828

4.  Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.

Authors:  Weiquan Li; Lizhong Wang; Hiroto Katoh; Runhua Liu; Pan Zheng; Yang Liu
Journal:  Cancer Res       Date:  2011-01-28       Impact factor: 12.701

5.  A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling.

Authors:  Masamichi Imajo; Koichi Miyatake; Akira Iimura; Atsumu Miyamoto; Eisuke Nishida
Journal:  EMBO J       Date:  2012-01-10       Impact factor: 11.598

Review 6.  VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs.

Authors:  Xiaochong Deng; Lin Fang
Journal:  Am J Cancer Res       Date:  2018-06-01       Impact factor: 6.166

7.  Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis.

Authors:  Chang-Ru Tsai; Aimee E Anderson; Sirisha Burra; Juyeon Jo; Michael J Galko
Journal:  Dev Biol       Date:  2017-05-14       Impact factor: 3.582

8.  Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Authors:  Manuel Valiente; Karuna Ganesh; Ekrem Emrah Er; Yilong Zou; Saloni Agrawal; Jing Hu; Bailey Griscom; Marc Rosenblum; Adrienne Boire; Edi Brogi; Filippo G Giancotti; Melitta Schachner; Srinivas Malladi; Joan Massagué
Journal:  Nat Cell Biol       Date:  2018-07-23       Impact factor: 28.824

9.  Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma.

Authors:  Yun-Yong Park; Bo Hwa Sohn; Randy L Johnson; Myoung-Hee Kang; Sang Bae Kim; Jae-Jun Shim; Lingegowda S Mangala; Ji Hoon Kim; Jeong Eun Yoo; Cristian Rodriguez-Aguayo; Sunila Pradeep; Jun Eul Hwang; Hee-Jin Jang; Hyun-Sung Lee; Rajesha Rupaimoole; Gabriel Lopez-Berestein; Woojin Jeong; Inn Sun Park; Young Nyun Park; Anil K Sood; Gordon B Mills; Ju-Seog Lee
Journal:  Hepatology       Date:  2015-11-26       Impact factor: 17.425

10.  Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner.

Authors:  Y Liu; G Wang; Y Yang; Z Mei; Z Liang; A Cui; T Wu; C-Y Liu; L Cui
Journal:  Oncogene       Date:  2015-09-21       Impact factor: 9.867
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