| Literature DB >> 25349446 |
Stéphanie Hermitte1, Claire Chazaud2.
Abstract
In amniotes, primitive endoderm (PrE) plays important roles not only for nutrient support but also as an inductive tissue required for embryo patterning. PrE is an epithelial monolayer that is visible shortly before embryo implantation and is one of the first three cell lineages produced by the embryo. We review here the molecular mechanisms that have been uncovered during the past 10 years on PrE and epiblast cell lineage specification within the inner cell mass of the blastocyst and on their subsequent steps of differentiation.Entities:
Keywords: blastocyst; cell differentiation; cell polarization; cell sorting; epithelium; lineage specification
Mesh:
Substances:
Year: 2014 PMID: 25349446 PMCID: PMC4216460 DOI: 10.1098/rstb.2013.0537
Source DB: PubMed Journal: Philos Trans R Soc Lond B Biol Sci ISSN: 0962-8436 Impact factor: 6.237