Literature DB >> 25347981

Enhancement of 18F-fluorodeoxyglucose metabolism in rat brain frontal cortex using a β3 adrenoceptor agonist.

M Reza Mirbolooki1, Kimberly N Schade, Cristian C Constantinescu, Min-Liang Pan, Jogeshwar Mukherjee.   

Abstract

We report the use of β3 adrenergic receptor mediated activation of rat brain frontal cortex using mirabegron (a selective β3 adrenoceptor agonist), measured by (18)F-FDG PET/CT. Another β3 agonist, CL 316,243, did not have this effect due to impermeability through the blood brain barrier (BBB), while atomoxetine, a norepinephrine transporter blocker, did increase (18)F-FDG uptake in the frontal cortex. Mirabegron exhibited a dose-dependent increase in frontal cortex (18)F-FDG uptake. These findings suggest a possible use of selective β3 adrenoceptor agonists in reversing regional glucose hypometabolism in the brain.
© 2014 Wiley Periodicals, Inc.

Entities:  

Keywords:  18F-FDG; Alzheimer's disease; frontal cortex; β3 adrenoceptor

Mesh：

Substances：

Year:  2014        PMID： 25347981      PMCID： PMC4275345          DOI： 10.1002/syn.21789

Source DB:  PubMed          Journal:  Synapse        ISSN： 0887-4476            Impact factor:   2.562


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