BACKGROUND/AIMS: Haemodialysis causes recurrent haemodynamic stress with subsequent ischaemic end-organ dysfunction. As dialysis prescriptions/schedules can be modified to lessen this circulatory stress, an easily applicable test to allow targeted interventions in vulnerable patients is urgently required. METHODS: Intra-dialytic central venous oxygen saturation (ScvO2) and clinical markers (including ultrafiltration, blood pressure) were measured in 18 prevalent haemodialysis patients. RESULTS: Pre-dialysis ScvO2 was 63.5 ± 13% and fell significantly to 56.4 ± 8% at end dialysis (p = 0.046). Ultrafiltration volume, a key driver of dialysis-induced myocardial ischaemia, inversely correlated to ScvO2 (r = -0.680, p = 0.015). CONCLUSIONS: This initial study demonstrates ScvO2 sampling is practical, with a potential clinical utility as an indicator of circulatory stress during dialysis.
BACKGROUND/AIMS: Haemodialysis causes recurrent haemodynamic stress with subsequent ischaemic end-organ dysfunction. As dialysis prescriptions/schedules can be modified to lessen this circulatory stress, an easily applicable test to allow targeted interventions in vulnerable patients is urgently required. METHODS: Intra-dialytic central venous oxygen saturation (ScvO2) and clinical markers (including ultrafiltration, blood pressure) were measured in 18 prevalent haemodialysis patients. RESULTS: Pre-dialysis ScvO2 was 63.5 ± 13% and fell significantly to 56.4 ± 8% at end dialysis (p = 0.046). Ultrafiltration volume, a key driver of dialysis-induced myocardial ischaemia, inversely correlated to ScvO2 (r = -0.680, p = 0.015). CONCLUSIONS: This initial study demonstrates ScvO2 sampling is practical, with a potential clinical utility as an indicator of circulatory stress during dialysis.
Authors: Jan Malik; Anna Valerianova; Vladimir Tuka; Pavel Trachta; Vladimira Bednarova; Zdenka Hruskova; Marcela Slavikova; Mitchell H Rosner; Vladimir Tesar Journal: ESC Heart Fail Date: 2021-03-23
Authors: David F Keane; Jochen G Raimann; Hanjie Zhang; Joanna Willetts; Stephan Thijssen; Peter Kotanko Journal: Kidney Int Date: 2021-02-17 Impact factor: 10.612
Authors: Hanjie Zhang; Lili Chan; Anna Meyring-Wösten; Israel Campos; Priscila Preciado; Jeroen P Kooman; Frank M van der Sande; Doris Fuertinger; Stephan Thijssen; Peter Kotanko Journal: Nephrol Dial Transplant Date: 2018-09-01 Impact factor: 5.992