Ronald E Gangnon1, Kristine E Lee2, Barbara E K Klein2, Sudha K Iyengar3, Theru A Sivakumaran4, Ronald Klein2. 1. Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison2Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison. 2. Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison. 3. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio5Department of Genetics and Ophthalmology, Case Western Reserve University, Cleveland, Ohio. 4. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio5Department of Genetics and Ophthalmology, Case Western Reserve University, Cleveland, Ohio6Division of Human Genetics, Cincinnati Children's Hospital Medical Ce.
Abstract
IMPORTANCE: Previous studies regarding the severity of age-related macular degeneration (AMD) in 1 eye and its prognostic implications for the fellow eye have focused on the incidence of neovascular AMD in the fellow eye of participants with neovascular AMD in the other eye. It is unclear to what extent the severity of AMD in 1 eye affects the incidence, progression, and regression of AMD in its fellow eye across the entire range of AMD severity. OBJECTIVE: To investigate the effect of the severity of AMD in 1 eye on the incidence, progression, and regression of AMD in the fellow eye. DESIGN, SETTING AND PARTICIPANTS: The Beaver Dam Eye Study is a longitudinal population-based study of age-related eye diseases conducted in the city and township of Beaver Dam, Wisconsin. Examinations were performed every 5 years over a 20-year period (from the baseline examination in 1988-1990 to 2008-2010). Study participants (n = 4379) were 43 to 86 years of age at the baseline examination. At baseline and in up to 4 subsequent examinations, retinal photographs were taken. MAIN OUTCOMES AND MEASURES: Incidence, progression, and regression of AMD (assessed by use of the Wisconsin Age-Related Maculopathy Grading System on retinal photographs and adjusted for age, sex, and the Y402H polymorphism in the complement factor H gene on chromosome 1q) and mortality. RESULTS: More severe AMD in 1 eye was associated with increased incidence of AMD and accelerated progression in its fellow eye (levels 1-2: hazard ratio [HR], 4.90 [95% CI, 4.26-5.63]; levels 2-3: HR, 2.09 [95% CI, 1.42-3.06]; levels 3-4: HR, 2.38 [95% CI, 1.74-3.25]; levels 4-5: HR, 2.46 [95% CI, 1.65-3.66]). Less severe AMD in 1 eye was associated with less progression of AMD in its fellow eye (levels 2-3: HR, 0.42 [95% CI, 0.33-0.55]; levels 3-4: HR, 0.50 [95% CI, 0.34-0.83]). We estimate that 51% of participants who develop any AMD always maintain AMD severity states within 1 step of each other between eyes; 90% of participants stay within 2 steps. CONCLUSIONS AND RELEVANCE: Using multistate models, we show that AMD severity in 1 eye tracks AMD severity in its fellow eye.
IMPORTANCE: Previous studies regarding the severity of age-related macular degeneration (AMD) in 1 eye and its prognostic implications for the fellow eye have focused on the incidence of neovascular AMD in the fellow eye of participants with neovascular AMD in the other eye. It is unclear to what extent the severity of AMD in 1 eye affects the incidence, progression, and regression of AMD in its fellow eye across the entire range of AMD severity. OBJECTIVE: To investigate the effect of the severity of AMD in 1 eye on the incidence, progression, and regression of AMD in the fellow eye. DESIGN, SETTING AND PARTICIPANTS: The Beaver Dam Eye Study is a longitudinal population-based study of age-related eye diseases conducted in the city and township of Beaver Dam, Wisconsin. Examinations were performed every 5 years over a 20-year period (from the baseline examination in 1988-1990 to 2008-2010). Study participants (n = 4379) were 43 to 86 years of age at the baseline examination. At baseline and in up to 4 subsequent examinations, retinal photographs were taken. MAIN OUTCOMES AND MEASURES: Incidence, progression, and regression of AMD (assessed by use of the Wisconsin Age-Related Maculopathy Grading System on retinal photographs and adjusted for age, sex, and the Y402H polymorphism in the complement factor H gene on chromosome 1q) and mortality. RESULTS: More severe AMD in 1 eye was associated with increased incidence of AMD and accelerated progression in its fellow eye (levels 1-2: hazard ratio [HR], 4.90 [95% CI, 4.26-5.63]; levels 2-3: HR, 2.09 [95% CI, 1.42-3.06]; levels 3-4: HR, 2.38 [95% CI, 1.74-3.25]; levels 4-5: HR, 2.46 [95% CI, 1.65-3.66]). Less severe AMD in 1 eye was associated with less progression of AMD in its fellow eye (levels 2-3: HR, 0.42 [95% CI, 0.33-0.55]; levels 3-4: HR, 0.50 [95% CI, 0.34-0.83]). We estimate that 51% of participants who develop any AMD always maintain AMD severity states within 1 step of each other between eyes; 90% of participants stay within 2 steps. CONCLUSIONS AND RELEVANCE: Using multistate models, we show that AMD severity in 1 eye tracks AMD severity in its fellow eye.
Authors: Ronald E Gangnon; Kristine E Lee; Barbara E K Klein; Sudha K Iyengar; Theru A Sivakumaran; Ronald Klein Journal: Invest Ophthalmol Vis Sci Date: 2014-03-20 Impact factor: 4.799
Authors: Ronald Klein; Kristine E Lee; Michael Y Tsai; Karen J Cruickshanks; Ronald E Gangnon; Barbara E K Klein Journal: Ophthalmology Date: 2018-12-17 Impact factor: 12.079
Authors: Nichole Joachim; Johanna Maria Colijn; Annette Kifley; Kristine E Lee; Gabriëlle H S Buitendijk; Barbara E K Klein; Chelsea E Myers; Stacy M Meuer; Ava G Tan; Elizabeth G Holliday; John Attia; Gerald Liew; Sudha K Iyengar; Paulus T V M de Jong; Albert Hofman; Johannes R Vingerling; Paul Mitchell; Caroline C W Klaver; Ronald Klein; Jie Jin Wang Journal: Br J Ophthalmol Date: 2017-01-20 Impact factor: 4.638
Authors: Aniruddha Agarwal; William R Rhoades; Mostafa Hanout; Mohamed Kamel Soliman; Salman Sarwar; Mohammad Ali Sadiq; Yasir Jamal Sepah; Diana V Do; Quan Dong Nguyen Journal: Clin Ophthalmol Date: 2015-06-05
Authors: Rebecca J Sardell; Patrice J Persad; Samuel S Pan; Patrice Whitehead; Larry D Adams; Reneé A Laux; Jorge A Fortun; Milam A Brantley; Jaclyn L Kovach; Stephen G Schwartz; Anita Agarwal; Jonathan L Haines; William K Scott; Margaret A Pericak-Vance Journal: Invest Ophthalmol Vis Sci Date: 2016-11-01 Impact factor: 4.799