Literature DB >> 25340311

Suppression of nanoparticle cytotoxicity approaching in vivo serum concentrations: limitations of in vitro testing for nanosafety.

Jong Ah Kim1, Anna Salvati, Christoffer Åberg, Kenneth A Dawson.   

Abstract

Nanomaterials challenge paradigms of in vitro testing because unlike molecular species, biomolecules in the dispersion medium modulate their interactions with cells. Exposing cells to nanoparticles known to cause cell death, we observed cytotoxicity suppression by increasing the amount of serum in the dispersion medium towards in vivo-relevant conditions.

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Year:  2014        PMID： 25340311     DOI： 10.1039/c4nr04970e

Source DB:  PubMed          Journal:  Nanoscale        ISSN： 2040-3364            Impact factor:   7.790


  27 in total

1.  Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles.

Authors:  Christina L Wilson; Vaishaali Natarajan; Stephen L Hayward; Oleh Khalimonchuk; Srivatsan Kidambi
Journal:  Nanoscale       Date:  2015-08-14       Impact factor: 7.790

2.  How should the completeness and quality of curated nanomaterial data be evaluated?

Authors:  Richard L Marchese Robinson; Iseult Lynch; Willie Peijnenburg; John Rumble; Fred Klaessig; Clarissa Marquardt; Hubert Rauscher; Tomasz Puzyn; Ronit Purian; Christoffer Åberg; Sandra Karcher; Hanne Vriens; Peter Hoet; Mark D Hoover; Christine Ogilvie Hendren; Stacey L Harper
Journal:  Nanoscale       Date:  2016-05-04       Impact factor: 7.790

3.  Polyserotonin Nanoparticles as Multifunctional Materials for Biomedical Applications.

Authors:  Nako Nakatsuka; Mohammad Mahdi Hasani-Sadrabadi; Kevin M Cheung; Thomas D Young; Ghasem Bahlakeh; Alireza Moshaverinia; Paul S Weiss; Anne M Andrews
Journal:  ACS Nano       Date:  2018-04-30       Impact factor: 15.881

4.  The Protein Corona around Nanoparticles Facilitates Stem Cell Labeling for Clinical MR Imaging.

Authors:  Hossein Nejadnik; Seyed-Meghdad Taghavi-Garmestani; Steven J Madsen; Kai Li; Saeid Zanganeh; Phillip Yang; Morteza Mahmoudi; Heike E Daldrup-Link
Journal:  Radiology       Date:  2017-11-01       Impact factor: 11.105

5.  Studying the Effects of Cysteine Residues on Protein Interactions with Silver Nanoparticles.

Authors:  Kumudu Siriwardana; Ailin Wang; Manuel Gadogbe; Willard E Collier; Nicholas C Fitzkee; Dongmao Zhang
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2015       Impact factor: 4.126

6.  Independent effect of polymeric nanoparticle zeta potential/surface charge, on their cytotoxicity and affinity to cells.

Authors:  Xiao-Ru Shao; Xue-Qin Wei; Xu Song; Li-Ying Hao; Xiao-Xiao Cai; Zhi-Rong Zhang; Qiang Peng; Yun-Feng Lin
Journal:  Cell Prolif       Date:  2015-05-27       Impact factor: 6.831

7.  Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi-peptide nanoparticles to tumour-associated macrophages and cancer cells.

Authors:  João Conde; Chenchen Bao; Yeqi Tan; Daxiang Cui; Elazer R Edelman; Helena S Azevedo; Hugh J Byrne; Natalie Artzi; Furong Tian
Journal:  Adv Funct Mater       Date:  2015-06-01       Impact factor: 18.808

Review 8.  Hurdles in selection process of nanodelivery systems for multidrug-resistant cancer.

Authors:  P S Thakur; A M Khan; S Talegaonkar; F J Ahmad; Z Iqbal
Journal:  J Cancer Res Clin Oncol       Date:  2016-04-26       Impact factor: 4.553

Review 9.  The biomechanisms of metal and metal-oxide nanoparticles' interactions with cells.

Authors:  Sondra S Teske; Corrella S Detweiler
Journal:  Int J Environ Res Public Health       Date:  2015-01-22       Impact factor: 3.390

10.  Modulation of Silica Nanoparticle Uptake into Human Osteoblast Cells by Variation of the Ratio of Amino and Sulfonate Surface Groups: Effects of Serum.

Authors:  Shakiba Shahabi; Laura Treccani; Ralf Dringen; Kurosch Rezwan
Journal:  ACS Appl Mater Interfaces       Date:  2015-06-21       Impact factor: 9.229
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