| Literature DB >> 25340261 |
Zulfiqar Ali1, Neeraj Mishra1, Ashish Baldi1.
Abstract
The purpose of the present work is to improve the antimalarial activity of the drug arteether (AE) by enhancing its solubility, by loading it into a nanostructured lipid carrier (NLC). The in vitro drug release profile of the NLC showed 93% drug release in 32 h. Complete eradication of the parasite from the blood and efficient anti-malarial pharmacological activity were observed, with the use of AE-loaded NLCs. These results suggest that nanolipid carriers of AE could be a promising carrier system to deliver the poorly soluble antimalarial drug through the oral route, by enhancing its solubility as well as preventing its degradation in the stomach.Entities:
Keywords: antimalarial activity; arteether; in vivo studies; nanolipid carrier; solubility
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Year: 2014 PMID： 25340261 DOI： 10.3109/21691401.2014.968821
Source DB: PubMed Journal: Artif Cells Nanomed Biotechnol ISSN： 2169-1401 Impact factor: 5.678