Ni Tang1, Cehua Ou2, Yulin Liu2, Yunxia Zuo3, Yipping Bai2. 1. Department of Anaesthesia, West China Hospital, Sichuan University, Chengdu, China. 2. Department of Anaesthesia, The Affiliated Hospital of Luzhou Medical College, Luzhou, China. 3. Department of Anaesthesia, West China Hospital, Sichuan University, Chengdu, China 1440167389@qq.com.
Abstract
AIMS: To determine the effect of choice of inhalational anaesthetic (sevoflurane vs propofol) on the incidence and severity of postoperative cognitive dysfunction (POCD) in elderly patients (aged ≥ 60 years) with mild cognitive impairment (MCI). METHODS:Elderly patients with MCI undergoing radical rectal resection were randomly assigned to receive sevoflurane or propofol general anaesthesia. Cognitive function was assessed using neuropsychological testing before and 7 days after surgery. POCD severity was graded as mild, moderate or severe using standard deviation cut-offs. RESULTS: At 7 days after surgery, the incidence of POCD was 29.7% in the propofol group (n = 101) and 33.3% in the sevoflurane group (n = 99). There was a significant between-group difference for POCD severity: sevoflurane anaesthesia had a more severe impact on cognitive function than propofol anaesthesia. CONCLUSIONS: There was no difference in the incidence of POCD at 7 days after radical rectal resection under sevoflurane or propofol-based general anaesthesia. Both propofol and sevoflurane were associated with negative cognitive effects, but sevoflurane had a more severe impact on cognitive function than propofol, in elderly patients with MCI.
RCT Entities:
AIMS: To determine the effect of choice of inhalational anaesthetic (sevoflurane vs propofol) on the incidence and severity of postoperative cognitive dysfunction (POCD) in elderly patients (aged ≥ 60 years) with mild cognitive impairment (MCI). METHODS: Elderly patients with MCI undergoing radical rectal resection were randomly assigned to receive sevoflurane or propofol general anaesthesia. Cognitive function was assessed using neuropsychological testing before and 7 days after surgery. POCD severity was graded as mild, moderate or severe using standard deviation cut-offs. RESULTS: At 7 days after surgery, the incidence of POCD was 29.7% in the propofol group (n = 101) and 33.3% in the sevoflurane group (n = 99). There was a significant between-group difference for POCD severity: sevoflurane anaesthesia had a more severe impact on cognitive function than propofol anaesthesia. CONCLUSIONS: There was no difference in the incidence of POCD at 7 days after radical rectal resection under sevoflurane or propofol-based general anaesthesia. Both propofol and sevoflurane were associated with negative cognitive effects, but sevoflurane had a more severe impact on cognitive function than propofol, in elderly patients with MCI.
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