BACKGROUND: The relationship between fat distribution and lymph node metastasis has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node metastasis in gastric cancer. MATERIALS AND METHODS: Metastatic lymph node ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected lymph nodes. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) >0.29. RESULTS: With lymph node metastasis as a dependent variable, the following factors were significant in multivariate analysis among 495 patients: pathologic T stage (P < 0.001), lympho-vascular invasion (P < 0.001), and V/T (hazard ratio (HR) = 0.455, 95 % confidence interval (CI) = 0.263-0.786, P = 0.005). Similarly, when MLR was the dependent variable in multivariate analysis, MLR was significantly associated with lympho-vascular invasion (HR = 2.222, 95 % CI = 1.149-4.296, P = 0.018), and V/T (HR = 0.247, 95 % CI = 0.133-0.458, P < 0.001). CONCLUSIONS: Visceral obesity defined by higher visceral to total fat area ratio was significantly associated with decreased MLR.
BACKGROUND: The relationship between fat distribution and lymph node metastasis has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node metastasis in gastric cancer. MATERIALS AND METHODS: Metastatic lymph node ratio (MLR) was defined as the number of involved nodes by tumor divided by the total number of resected lymph nodes. Visceral (VFA) and subcutaneous fat areas (SFA) were determined by measuring abdominal fat volume distribution via CT scan, and visceral obesity was defined as a VFA to total fat area ratio (V/T) >0.29. RESULTS: With lymph node metastasis as a dependent variable, the following factors were significant in multivariate analysis among 495 patients: pathologic T stage (P < 0.001), lympho-vascular invasion (P < 0.001), and V/T (hazard ratio (HR) = 0.455, 95 % confidence interval (CI) = 0.263-0.786, P = 0.005). Similarly, when MLR was the dependent variable in multivariate analysis, MLR was significantly associated with lympho-vascular invasion (HR = 2.222, 95 % CI = 1.149-4.296, P = 0.018), and V/T (HR = 0.247, 95 % CI = 0.133-0.458, P < 0.001). CONCLUSIONS:Visceral obesity defined by higher visceral to total fat area ratio was significantly associated with decreased MLR.
Authors: J Kulig; M Sierzega; P Kolodziejczyk; J Dadan; M Drews; M Fraczek; A Jeziorski; M Krawczyk; T Starzynska; G Wallner Journal: Eur J Surg Oncol Date: 2010-08-21 Impact factor: 4.424
Authors: Darcy B Carr; Kristina M Utzschneider; Rebecca L Hull; Keiichi Kodama; Barbara M Retzlaff; John D Brunzell; Jane B Shofer; Brian E Fish; Robert H Knopp; Steven E Kahn Journal: Diabetes Date: 2004-08 Impact factor: 9.461
Authors: Jung Hwan Lee; Boram Park; Jungnam Joo; Myeong-Cherl Kook; Young-Il Kim; Jong Yeul Lee; Chan Gyoo Kim; Il Ju Choi; Bang Wool Eom; Hong Man Yoon; Keun Won Ryu; Young-Woo Kim; Soo-Jeong Cho Journal: Gastric Cancer Date: 2018-04-12 Impact factor: 7.370
Authors: Ji Yeong An; Jae Seok Min; Young Joon Lee; Sang Ho Jeong; Hoon Hur; Sang Uk Han; Woo Jin Hyung; Gyu Seok Cho; Gui Ae Jeong; Oh Jeong; Young Kyu Park; Mi Ran Jung; Ji Yeon Park; Young Woo Kim; Hong Man Yoon; Bang Wool Eom; Keun Won Ryu Journal: Gastroenterol Res Pract Date: 2017-06-15 Impact factor: 2.260