Akihiko Okamura1, Masayuki Watanabe2, Kotaro Yamashita1, Masami Yuda1, Masaru Hayami1, Yu Imamura, Shinji Mine1. 1. Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. 2. Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. masayuki.watanabe@jfcr.or.jp.
Abstract
PURPOSE: Visceral obesity is considered to be associated not only with chronic systemic inflammation but also with aggressive cancer behavior. However, the implication of visceral obesity in patients with esophageal squamous cell carcinoma (ESCC) is unclear. METHODS: Computed tomography volumetry was performed in 364 patients who underwent esophagectomy for ESCC. We calculated the ratio of the visceral fat area to the subcutaneous fat area (VS ratio), which is a valuable parameter of visceral obesity. Then, the clinicopathological characteristics were compared between patients with low VS ratio and those with high VS ratio. RESULTS: Overall and disease-specific survivals of patients with high VS ratio were significantly worse than those with low VS ratio (P < 0.001 in both). Patients with high VS ratio had considerably more advanced pN factor, higher prevalence of lymphatic invasion, and more number of metastatic lymph nodes than those with low VS ratio (P = 0.044, < 0.001, and 0.006, respectively). Among patients who received preoperative treatment, high VS ratio correlated with poor response to preoperative treatment (P = 0.040). CONCLUSIONS: Visceral obesity was associated with lymphatic invasiveness and poor response to preoperative treatment in patients with ESCC, which may negatively influence their prognosis.
PURPOSE:Visceral obesity is considered to be associated not only with chronic systemic inflammation but also with aggressive cancer behavior. However, the implication of visceral obesity in patients with esophageal squamous cell carcinoma (ESCC) is unclear. METHODS: Computed tomography volumetry was performed in 364 patients who underwent esophagectomy for ESCC. We calculated the ratio of the visceral fat area to the subcutaneous fat area (VS ratio), which is a valuable parameter of visceral obesity. Then, the clinicopathological characteristics were compared between patients with low VS ratio and those with high VS ratio. RESULTS: Overall and disease-specific survivals of patients with high VS ratio were significantly worse than those with low VS ratio (P < 0.001 in both). Patients with high VS ratio had considerably more advanced pN factor, higher prevalence of lymphatic invasion, and more number of metastatic lymph nodes than those with low VS ratio (P = 0.044, < 0.001, and 0.006, respectively). Among patients who received preoperative treatment, high VS ratio correlated with poor response to preoperative treatment (P = 0.040). CONCLUSIONS:Visceral obesity was associated with lymphatic invasiveness and poor response to preoperative treatment in patients with ESCC, which may negatively influence their prognosis.
Authors: Rob C M van Kruijsdijk; Elsken van der Wall; Frank L J Visseren Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-09-15 Impact factor: 4.254
Authors: Joao Incio; Hao Liu; Priya Suboj; Shan M Chin; Ivy X Chen; Matthias Pinter; Mei R Ng; Hadi T Nia; Jelena Grahovac; Shannon Kao; Suboj Babykutty; Yuhui Huang; Keehoon Jung; Nuh N Rahbari; Xiaoxing Han; Vikash P Chauhan; John D Martin; Julia Kahn; Peigen Huang; Vikram Desphande; James Michaelson; Theodoros P Michelakos; Cristina R Ferrone; Raquel Soares; Yves Boucher; Dai Fukumura; Rakesh K Jain Journal: Cancer Discov Date: 2016-05-31 Impact factor: 39.397
Authors: Kyle E Freese; Lauren Kokai; Robert P Edwards; Brian J Philips; M Aamir Sheikh; Joseph Kelley; John Comerci; Kacey G Marra; J Peter Rubin; Faina Linkov Journal: Cancer Res Date: 2015-03-03 Impact factor: 12.701
Authors: Camila T B Gabiatti; Mariane C L Martins; Daniela L Miyazaki; Leandro P Silva; Fabiana Lascala; Ligia T Macedo; Maria Carolina Santos Mendes; José Barreto Campello Carvalheira Journal: Cancer Med Date: 2019-10-01 Impact factor: 4.452
Authors: Eliza R C Hagens; Minke L Feenstra; Maarten A van Egmond; Hanneke W M van Laarhoven; Maarten C C M Hulshof; Piers R Boshier; Donald E Low; Mark I van Berge Henegouwen; Suzanne S Gisbertz Journal: J Cachexia Sarcopenia Muscle Date: 2020-02-25 Impact factor: 12.910