| Literature DB >> 25337212 |
Xin Wang1, Mi Gao1, Yuan Xu2, Huamin Guo1, Chunyuan Zhao1.
Abstract
In order to explore the role of IL-22 in the pathogenesis of CRS, we observed the expression of IL-22 and associated factors in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Immunohistochemical staining was applied to detect the expression of IL-22, IL-22R, STAT3, retinoic acid orphan receptor C (RORC) and aryl hydrocarbon recptor (AhR). There was significantly higher expression of IL-22 in CRSsNP than in controls (P<0.05). But the expression of IL-22 had no significant difference when comparing CRSwNP with CRSsNP and controls. The expression of IL-22R was significantly lower in CRSwNP compared to controls and CRSsNP (P<0.05). The expression of AhR was lower in CRSwNP than in CRSsNP (P<0.05). There was no significant difference of RORC and STAT3 among CRSwNP, CRSsNP and controls. IL-22 plays the important role in the pathogenesis of CRS, and further research is needed to understand the complex interactions with other cytokines and the exact mechanism of transcriptional regulation for IL-22.Entities:
Keywords: Chronic rhinosinusitis; IL-22; IL-22 receptor; aryl hydrocarbon recptor
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Year: 2014 PMID： 25337212 PMCID： PMC4203183
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625