Literature DB >> 25336699

New, tolerable γ-secretase inhibitor takes desmoid down a notch.

Dennis P M Hughes1, Shivaani Kummar2, Alexander J Lazar3.   

Abstract

A phase I trial of PF-03084014, an oral reversible γ-secretase inhibitor, in solid tumor malignancies shows drug tolerability in patients. Evidence of Notch pathway inhibition was demonstrated in peripheral blood. A surprisingly high rate of response was seen in desmoid tumors, a rare but sometimes locally aggressive sarcoma. ©2014 American Association for Cancer Research.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25336699      PMCID： PMC4306586          DOI： 10.1158/1078-0432.CCR-14-1660

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  11 in total

Review 1.  The double-edged sword of Notch signaling in cancer.

Authors:  Andrew P South; Raymond J Cho; Jon C Aster
Journal:  Semin Cell Dev Biol       Date:  2012-01-30       Impact factor: 7.727

Review 2.  Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

Authors:  Bart De Strooper; Takeshi Iwatsubo; Michael S Wolfe
Journal:  Cold Spring Harb Perspect Med       Date:  2012-01       Impact factor: 6.915

3.  Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness.

Authors:  P Zhang; Y Yang; R Nolo; P A Zweidler-McKay; D P M Hughes
Journal:  Oncogene       Date:  2010-03-08       Impact factor: 9.867

Review 4.  Notch as a hub for signaling in angiogenesis.

Authors:  Rui Benedito; Mats Hellström
Journal:  Exp Cell Res       Date:  2013-01-15       Impact factor: 3.905

5.  A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.

Authors:  Wells A Messersmith; Geoffrey I Shapiro; James M Cleary; Antonio Jimeno; Arvind Dasari; Bo Huang; M Naveed Shaik; Rossano Cesari; Xianxian Zheng; Jennifer M Reynolds; Patricia A English; Karen R McLachlan; Kenneth A Kern; Patricia M LoRusso
Journal:  Clin Cancer Res       Date:  2014-09-17       Impact factor: 12.531

Review 6.  Targeting notch signaling pathway in cancer: clinical development advances and challenges.

Authors:  Naoko Takebe; Dat Nguyen; Sherry X Yang
Journal:  Pharmacol Ther       Date:  2013-09-27       Impact factor: 12.310

7.  Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.

Authors:  Ian Krop; Tim Demuth; Tina Guthrie; Patrick Y Wen; Warren P Mason; Prakash Chinnaiyan; Nicholas Butowski; Morris D Groves; Santosh Kesari; Steven J Freedman; Samuel Blackman; James Watters; Andrey Loboda; Alexei Podtelezhnikov; Jared Lunceford; Cong Chen; Maxine Giannotti; Jeremy Hing; Robert Beckman; Patricia Lorusso
Journal:  J Clin Oncol       Date:  2012-04-30       Impact factor: 44.544

Review 8.  The Notch signaling pathway as a mediator of tumor survival.

Authors:  Kathleen M Capaccione; Sharon R Pine
Journal:  Carcinogenesis       Date:  2013-04-12       Impact factor: 4.944

9.  Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors.

Authors:  Alexander J F Lazar; Daniel Tuvin; Shohrae Hajibashi; Sultan Habeeb; Svetlana Bolshakov; Empar Mayordomo-Aranda; Carla L Warneke; Dolores Lopez-Terrada; Raphael E Pollock; Dina Lev
Journal:  Am J Pathol       Date:  2008-10-02       Impact factor: 4.307

10.  Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry.

Authors:  Michael J Kluk; Todd Ashworth; Hongfang Wang; Birgit Knoechel; Emily F Mason; Elizabeth A Morgan; David Dorfman; Geraldine Pinkus; Oliver Weigert; Jason L Hornick; Lucian R Chirieac; Michelle Hirsch; David J Oh; Andrew P South; Irene M Leigh; Celine Pourreyron; Andrew J Cassidy; Daniel J Deangelo; David M Weinstock; Ian E Krop; Deborah Dillon; Jane E Brock; Alexander J F Lazar; Myron Peto; Raymond J Cho; Alexander Stoeck; Brian B Haines; Sriram Sathayanrayanan; Scott Rodig; Jon C Aster
Journal:  PLoS One       Date:  2013-06-18       Impact factor: 3.240
View more
  10 in total

1.  Zebrafish phenotypic screen identifies novel Notch antagonists.

Authors:  Vithya Velaithan; Kazuhide Shaun Okuda; Mei Fong Ng; Norazwana Samat; Sze Wei Leong; Siti Munirah Mohd Faudzi; Faridah Abas; Khozirah Shaari; Sok Ching Cheong; Pei Jean Tan; Vyomesh Patel
Journal:  Invest New Drugs       Date:  2017-01-05       Impact factor: 3.850

2.  Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics.

Authors:  Sadakatsu Ikeda; Jordan S Lim; Razelle Kurzrock
Journal:  Mol Cancer Ther       Date:  2018-02-26       Impact factor: 6.261

3.  AB4 inhibits Notch signaling and promotes cancer cell apoptosis in liver cancer.

Authors:  Zhuo Xiang; Qing Miao; Jin Zhang; Yang Liu; Guoxin Liu; Shuyi Xue; Xu Liu; Zhe Zhang; Lixia Shen; Bangguo Liu; Yu Zhou; Ting Miao
Journal:  Oncol Rep       Date:  2021-04-28       Impact factor: 3.906

Review 4.  Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy.

Authors:  Rocio K Rivera-Valentin; Limin Zhu; Dennis P M Hughes
Journal:  Paediatr Drugs       Date:  2015-08       Impact factor: 3.022

5.  NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.

Authors:  Zhi-Li Zhao; Lu Zhang; Cong-Fa Huang; Si-Rui Ma; Lin-Lin Bu; Jian-Feng Liu; Guang-Tao Yu; Bing Liu; J Silvio Gutkind; Ashok B Kulkarni; Wen-Feng Zhang; Zhi-Jun Sun
Journal:  Sci Rep       Date:  2016-04-25       Impact factor: 4.379

Review 6.  Advances in sarcoma diagnostics and treatment.

Authors:  Amanda R Dancsok; Karama Asleh-Aburaya; Torsten O Nielsen
Journal:  Oncotarget       Date:  2017-01-24

Review 7.  Intra-Abdominal and Abdominal Wall Desmoid Fibromatosis.

Authors:  J Harrison Howard; Raphael E Pollock
Journal:  Oncol Ther       Date:  2016-02-03

8.  Aggressive fibromatosis response to tamoxifen: lack of correlation between MRI and symptomatic response.

Authors:  M Libertini; I Mitra; W T A van der Graaf; A B Miah; I Judson; R L Jones; K Thomas; E Moskovic; Z Szucs; C Benson; C Messiou
Journal:  Clin Sarcoma Res       Date:  2018-05-14

9.  Fibromatosis - immunohistochemical evaluation, differential diagnosis from gastrointestinal tumors, and other mesenchymal tumours.

Authors:  Dorota E Lacka; Anna Nasierowska-Guttmejer
Journal:  Prz Gastroenterol       Date:  2019-03-12

10.  Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors.

Authors:  Hui Shang; Danielle Braggio; Ya-Jung Lee; Ghadah A Al Sannaa; Chad J Creighton; Svetlana Bolshakov; Alexander J F Lazar; Dina Lev; Raphael E Pollock
Journal:  Cancer       Date:  2015-09-08       Impact factor: 6.860
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.