Literature DB >> 22309843

The double-edged sword of Notch signaling in cancer.

Andrew P South1, Raymond J Cho, Jon C Aster.   

Abstract

Recent deep sequencing of cancer genomes has produced an explosion of new data implicating Notch signaling in several human cancers. Unlike most other pathways, these data indicate that Notch signaling can be either oncogenic or tumor suppressive, depending on the cellular context. In some instances, these relationships were predicted from mouse models or presaged by developmental roles for Notch, but in other cases were unanticipated. This review discusses the pathogenic and translational significance of these new findings.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22309843      PMCID： PMC3360804          DOI： 10.1016/j.semcdb.2012.01.017

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  48 in total

1.  NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL.

Authors:  Paolo Sportoletti; Stefano Baldoni; Laura Cavalli; Beatrice Del Papa; Elisabetta Bonifacio; Raffaella Ciurnelli; Alain Sylvin Bell; Ambra Di Tommaso; Emanuela Rosati; Barbara Crescenzi; Cristina Mecucci; Isabella Screpanti; Pierfrancesco Marconi; Massimo F Martelli; Mauro Di Ianni; Franca Falzetti
Journal:  Br J Haematol       Date:  2010-08-31       Impact factor: 6.998

2.  Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.

Authors:  Xose S Puente; Magda Pinyol; Víctor Quesada; Laura Conde; Gonzalo R Ordóñez; Neus Villamor; Georgia Escaramis; Pedro Jares; Sílvia Beà; Marcos González-Díaz; Laia Bassaganyas; Tycho Baumann; Manel Juan; Mónica López-Guerra; Dolors Colomer; José M C Tubío; Cristina López; Alba Navarro; Cristian Tornador; Marta Aymerich; María Rozman; Jesús M Hernández; Diana A Puente; José M P Freije; Gloria Velasco; Ana Gutiérrez-Fernández; Dolors Costa; Anna Carrió; Sara Guijarro; Anna Enjuanes; Lluís Hernández; Jordi Yagüe; Pilar Nicolás; Carlos M Romeo-Casabona; Heinz Himmelbauer; Ester Castillo; Juliane C Dohm; Silvia de Sanjosé; Miguel A Piris; Enrique de Alava; Jesús San Miguel; Romina Royo; Josep L Gelpí; David Torrents; Modesto Orozco; David G Pisano; Alfonso Valencia; Roderic Guigó; Mónica Bayés; Simon Heath; Marta Gut; Peter Klatt; John Marshall; Keiran Raine; Lucy A Stebbings; P Andrew Futreal; Michael R Stratton; Peter J Campbell; Ivo Gut; Armando López-Guillermo; Xavier Estivill; Emili Montserrat; Carlos López-Otín; Elías Campo
Journal:  Nature       Date:  2011-06-05       Impact factor: 49.962

3.  Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.

Authors:  Bo Zhao; James Zou; Hongfang Wang; Eric Johannsen; Chih-wen Peng; John Quackenbush; Jessica C Mar; Cynthia Casson Morton; Matthew L Freedman; Stephen C Blacklow; Jon C Aster; Bradley E Bernstein; Elliott Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-11       Impact factor: 11.205

4.  Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.

Authors:  Violetta V Leshchenko; Pei-Yu Kuo; Rita Shaknovich; David T Yang; Tobias Gellen; Adam Petrich; Yiting Yu; Yvonne Remache; Marc A Weniger; Sarwish Rafiq; K Stephen Suh; Andre Goy; Wyndham Wilson; Amit Verma; Ira Braunschweig; Natarajan Muthusamy; Brad S Kahl; John C Byrd; Adrian Wiestner; Ari Melnick; Samir Parekh
Journal:  Blood       Date:  2010-04-28       Impact factor: 22.113

5.  Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.

Authors:  Nishant Agrawal; Mitchell J Frederick; Curtis R Pickering; Chetan Bettegowda; Kyle Chang; Ryan J Li; Carole Fakhry; Tong-Xin Xie; Jiexin Zhang; Jing Wang; Nianxiang Zhang; Adel K El-Naggar; Samar A Jasser; John N Weinstein; Lisa Treviño; Jennifer A Drummond; Donna M Muzny; Yuanqing Wu; Laura D Wood; Ralph H Hruban; William H Westra; Wayne M Koch; Joseph A Califano; Richard A Gibbs; David Sidransky; Bert Vogelstein; Victor E Velculescu; Nickolas Papadopoulos; David A Wheeler; Kenneth W Kinzler; Jeffrey N Myers
Journal:  Science       Date:  2011-07-28       Impact factor: 47.728

6.  The mutational landscape of head and neck squamous cell carcinoma.

Authors:  Nicolas Stransky; Ann Marie Egloff; Aaron D Tward; Aleksandar D Kostic; Kristian Cibulskis; Andrey Sivachenko; Gregory V Kryukov; Michael S Lawrence; Carrie Sougnez; Aaron McKenna; Erica Shefler; Alex H Ramos; Petar Stojanov; Scott L Carter; Douglas Voet; Maria L Cortés; Daniel Auclair; Michael F Berger; Gordon Saksena; Candace Guiducci; Robert C Onofrio; Melissa Parkin; Marjorie Romkes; Joel L Weissfeld; Raja R Seethala; Lin Wang; Claudia Rangel-Escareño; Juan Carlos Fernandez-Lopez; Alfredo Hidalgo-Miranda; Jorge Melendez-Zajgla; Wendy Winckler; Kristin Ardlie; Stacey B Gabriel; Matthew Meyerson; Eric S Lander; Gad Getz; Todd R Golub; Levi A Garraway; Jennifer R Grandis
Journal:  Science       Date:  2011-07-28       Impact factor: 47.728

7.  Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Authors:  Nicholas J Wang; Zachary Sanborn; Kelly L Arnett; Laura J Bayston; Wilson Liao; Charlotte M Proby; Irene M Leigh; Eric A Collisson; Patricia B Gordon; Lakshmi Jakkula; Sally Pennypacker; Yong Zou; Mimansa Sharma; Jeffrey P North; Swapna S Vemula; Theodora M Mauro; Isaac M Neuhaus; Philip E Leboit; Joe S Hur; Kyunghee Park; Nam Huh; Pui-Yan Kwok; Sarah T Arron; Pierre P Massion; Allen E Bale; David Haussler; James E Cleaver; Joe W Gray; Paul T Spellman; Andrew P South; Jon C Aster; Stephen C Blacklow; Raymond J Cho
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

8.  Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.

Authors:  Giulia Fabbri; Silvia Rasi; Davide Rossi; Vladimir Trifonov; Hossein Khiabanian; Jing Ma; Adina Grunn; Marco Fangazio; Daniela Capello; Sara Monti; Stefania Cresta; Ernesto Gargiulo; Francesco Forconi; Anna Guarini; Luca Arcaini; Marco Paulli; Luca Laurenti; Luigi M Larocca; Roberto Marasca; Valter Gattei; David Oscier; Francesco Bertoni; Charles G Mullighan; Robin Foá; Laura Pasqualucci; Raul Rabadan; Riccardo Dalla-Favera; Gianluca Gaidano
Journal:  J Exp Med       Date:  2011-06-13       Impact factor: 14.307

9.  A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

Authors:  Apostolos Klinakis; Camille Lobry; Omar Abdel-Wahab; Philmo Oh; Hiroshi Haeno; Silvia Buonamici; Inge van De Walle; Severine Cathelin; Thomas Trimarchi; Elisa Araldi; Cynthia Liu; Sherif Ibrahim; Miroslav Beran; Jiri Zavadil; Argiris Efstratiadis; Tom Taghon; Franziska Michor; Ross L Levine; Iannis Aifantis
Journal:  Nature       Date:  2011-05-12       Impact factor: 49.962

10.  Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.

Authors:  Dan R Robinson; Shanker Kalyana-Sundaram; Yi-Mi Wu; Sunita Shankar; Xuhong Cao; Bushra Ateeq; Irfan A Asangani; Matthew Iyer; Christopher A Maher; Catherine S Grasso; Robert J Lonigro; Michael Quist; Javed Siddiqui; Rohit Mehra; Xiaojun Jing; Thomas J Giordano; Michael S Sabel; Celina G Kleer; Nallasivam Palanisamy; Rachael Natrajan; Maryou B Lambros; Jorge S Reis-Filho; Chandan Kumar-Sinha; Arul M Chinnaiyan
Journal:  Nat Med       Date:  2011-11-20       Impact factor: 53.440
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  69 in total

Review 1.  Hypoxia, notch signalling, and prostate cancer.

Authors:  Laure Marignol; Karla Rivera-Figueroa; Thomas Lynch; Donal Hollywood
Journal:  Nat Rev Urol       Date:  2013-05-28       Impact factor: 14.432

2.  Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup.

Authors:  Casper Groth; Takeshi Sasamura; Mansi R Khanna; Michael Whitley; Mark E Fortini
Journal:  Development       Date:  2013-06-19       Impact factor: 6.868

3.  Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.

Authors:  Takashi Yugawa; Koichiro Nishino; Shin-Ichi Ohno; Tomomi Nakahara; Masatoshi Fujita; Naoki Goshima; Akihiro Umezawa; Tohru Kiyono
Journal:  Mol Cell Biol       Date:  2013-09-09       Impact factor: 4.272

Review 4.  Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.

Authors:  Rosalba Camicia; Hans C Winkler; Paul O Hassa
Journal:  Mol Cancer       Date:  2015-12-11       Impact factor: 27.401

5.  Fryl deficiency is associated with defective kidney development and function in mice.

Authors:  Yong-Sub Byun; Eun-Kyoung Kim; Kimi Araki; Ken-Ichi Yamamura; Kihoon Lee; Won-Kee Yoon; Young-Suk Won; Hyoung-Chin Kim; Kyung-Chul Choi; Ki-Hoan Nam
Journal:  Exp Biol Med (Maywood)       Date:  2018-02-06

Review 6.  The multiple roles of epidermal growth factor repeat O-glycans in animal development.

Authors:  Amanda R Haltom; Hamed Jafar-Nejad
Journal:  Glycobiology       Date:  2015-07-14       Impact factor: 4.313

7.  Notch2 regulates matrix metallopeptidase 9 via PI3K/AKT signaling in human gastric carcinoma cell MKN-45.

Authors:  Ling-Yun Guo; Yu-Min Li; Liang Qiao; Tao Liu; Yuan-Yuan Du; Jun-Qiang Zhang; Wen-Ting He; Yong-Xun Zhao; Dong-Qiang He
Journal:  World J Gastroenterol       Date:  2012-12-28       Impact factor: 5.742

Review 8.  Molecular mechanisms of viral oncogenesis in humans.

Authors:  Nathan A Krump; Jianxin You
Journal:  Nat Rev Microbiol       Date:  2018-11       Impact factor: 60.633

9.  Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis.

Authors:  Samantha Cialfi; Rocco Palermo; Sonia Manca; Carlo De Blasio; Paula Vargas Romero; Saula Checquolo; Diana Bellavia; Daniela Uccelletti; Michele Saliola; Angelo D'Alessandro; Lello Zolla; Alberto Gulino; Isabella Screpanti; Claudio Talora
Journal:  Cell Cycle       Date:  2014-05-06       Impact factor: 4.534

Review 10.  Lung cancer stem cells: progress and prospects.

Authors:  Amber Lundin; Barbara Driscoll
Journal:  Cancer Lett       Date:  2012-08-17       Impact factor: 8.679
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