Literature DB >> 25336649

The making of a sweet modification: structure and function of O-GlcNAc transferase.

John Janetzko1, Suzanne Walker2.   

Abstract

O-GlcNAc transferase is an essential mammalian enzyme responsible for transferring a single GlcNAc moiety from UDP-GlcNAc to specific serine/threonine residues of hundreds of nuclear and cytoplasmic proteins. This modification is dynamic and has been implicated in numerous signaling pathways. An unexpected second function for O-GlcNAc transferase as a protease involved in cleaving the epigenetic regulator HCF-1 has also been reported. Recent structural and biochemical studies that provide insight into the mechanism of glycosylation and HCF-1 cleavage will be described, with outstanding questions highlighted.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Crystal Structure; Enzymology; Glycosylation; Glycosyltransferase; Host Cell Factor 1; Ligand-binding Protein; O-GlcNAcylation

Mesh：

Substances：

Year:  2014        PMID： 25336649      PMCID： PMC4263849          DOI： 10.1074/jbc.R114.604405

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  94 in total

1.  Et tu, Grotthuss! and other unfinished stories.

Authors:  Samuel Cukierman
Journal:  Biochim Biophys Acta       Date:  2005-12-29

2.  Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.

Authors:  Salima Daou; Nazar Mashtalir; Ian Hammond-Martel; Helen Pak; Helen Yu; Guangchao Sui; Jodi L Vogel; Thomas M Kristie; El Bachir Affar
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-01       Impact factor: 11.205

3.  Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates.

Authors:  Brooke D Lazarus; Dona C Love; John A Hanover
Journal:  Glycobiology       Date:  2006-01-23       Impact factor: 4.313

4.  Homology between O-linked GlcNAc transferases and proteins of the glycogen phosphorylase superfamily.

Authors:  J O Wrabl; N V Grishin
Journal:  J Mol Biol       Date:  2001-11-30       Impact factor: 5.469

5.  The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides.

Authors:  T M Kristie; J L Pomerantz; T C Twomey; S A Parent; P A Sharp
Journal:  J Biol Chem       Date:  1995-03-03       Impact factor: 5.157

6.  Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).

Authors:  Qiao Zhang; Xiaoguang Liu; Wenqi Gao; Pishun Li; Jingli Hou; Jiwen Li; Jiemin Wong
Journal:  J Biol Chem       Date:  2014-01-06       Impact factor: 5.157

7.  Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases.

Authors:  Yanan Hu; Lan Chen; Sha Ha; Ben Gross; Brian Falcone; Deborah Walker; Maryam Mokhtarzadeh; Suzanne Walker
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-21       Impact factor: 11.205

8.  An equilibrium model of the metastable binding sites of alpha 2-macroglobulin and complement proteins C3 and C4.

Authors:  S A Khan; B W Erickson
Journal:  J Biol Chem       Date:  1982-10-25       Impact factor: 5.157

9.  O-GlcNAcylation of kinases.

Authors:  Wagner B Dias; Win D Cheung; Gerald W Hart
Journal:  Biochem Biophys Res Commun       Date:  2012-04-30       Impact factor: 3.575

10.  Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis.

Authors:  Sang-Hoon Shin; Dona C Love; John A Hanover
Journal:  Amino Acids       Date:  2010-09-08       Impact factor: 3.520
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  28 in total

1.  Minireview series on the thirtieth anniversary of research on O-GlcNAcylation of nuclear and cytoplasmic proteins: Nutrient regulation of cellular metabolism and physiology by O-GlcNAcylation.

Authors:  Gerald W Hart
Journal:  J Biol Chem       Date:  2014-10-21       Impact factor: 5.157

Review 2.  Protein O-GlcNAcylation: emerging mechanisms and functions.

Authors:  Xiaoyong Yang; Kevin Qian
Journal:  Nat Rev Mol Cell Biol       Date:  2017-05-10       Impact factor: 94.444

3.  O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1).

Authors:  Jie Tian; Qizhi Geng; Yuehe Ding; Ji Liao; Meng-Qiu Dong; Xingzhi Xu; Jing Li
Journal:  J Biol Chem       Date:  2016-04-14       Impact factor: 5.157

4.  Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes.

Authors:  Sho Sugahara; Shinji Kume; Masami Chin-Kanasaki; Issei Tomita; Mako Yasuda-Yamahara; Kosuke Yamahara; Naoko Takeda; Norihisa Osawa; Motoko Yanagita; Shin-Ichi Araki; Hiroshi Maegawa
Journal:  J Am Soc Nephrol       Date:  2019-05-01       Impact factor: 10.121

5.  Undetectable histone O-GlcNAcylation in mammalian cells.

Authors:  Jessica Gagnon; Salima Daou; Natalia Zamorano; Nicholas V G Iannantuono; Ian Hammond-Martel; Nazar Mashtalir; Eric Bonneil; Hugo Wurtele; Pierre Thibault; El Bachir Affar
Journal:  Epigenetics       Date:  2015       Impact factor: 4.528

6.  O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking.

Authors:  Kurutihalli S Vishwanatha; Nils Bäck; TuKiet T Lam; Richard E Mains; Betty A Eipper
Journal:  J Biol Chem       Date:  2016-03-09       Impact factor: 5.157

Review 7.  Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration.

Authors:  Ilhan Akan; Stephanie Olivier-Van Stichelen; Michelle R Bond; John A Hanover
Journal:  J Neurochem       Date:  2017-11-20       Impact factor: 5.372

8.  Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.

Authors:  Cassandra M Joiner; Zebulon G Levine; Chanat Aonbangkhen; Christina M Woo; Suzanne Walker
Journal:  J Am Chem Soc       Date:  2019-08-07       Impact factor: 15.419

Review 9.  Structural characterization of the O-GlcNAc cycling enzymes: insights into substrate recognition and catalytic mechanisms.

Authors:  Cassandra M Joiner; Hao Li; Jiaoyang Jiang; Suzanne Walker
Journal:  Curr Opin Struct Biol       Date:  2019-01-30       Impact factor: 6.809

10.  A small molecule that inhibits OGT activity in cells.

Authors:  Rodrigo F Ortiz-Meoz; Jiaoyang Jiang; Michael B Lazarus; Marina Orman; John Janetzko; Chenguang Fan; Damien Y Duveau; Zhi-Wei Tan; Craig J Thomas; Suzanne Walker
Journal:  ACS Chem Biol       Date:  2015-03-18       Impact factor: 5.100
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