Literature DB >> 27080259

O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1).

Jie Tian1, Qizhi Geng1, Yuehe Ding2, Ji Liao1, Meng-Qiu Dong2, Xingzhi Xu3, Jing Li4.   

Abstract

The anaphase promoting complex/cyclosome (APC/C) orchestrates various aspects of the eukaryotic cell cycle. One of its co-activators, Cdh1, is subject to myriad post-translational modifications, such as phosphorylation and ubiquitination. Herein we identify the O-linked N-acetylglucosamine (O-GlcNAc) modification that occurs on Cdh1. Cdh1 is O-GlcNAcylated in cultured cells and mouse brain extracts. Mass spectrometry identifies an O-GlcNAcylated peptide that neighbors a known phosphorylation site. Cell synchronization and mutation studies reveal that O-GlcNAcylation of Cdh1 may antagonize its phosphorylation. Our results thus reveal a pivotal role of O-GlcNAcylation in regulating APC/C activity.
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Cdh1; O-linked N-acetylglucosamine (O-GlcNAc); O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT); anaphase promoting complex/cyclosome (APC/C); cell cycle; mitosis; phosphorylation

Mesh：

Substances：

Year:  2016        PMID： 27080259      PMCID： PMC4933264          DOI： 10.1074/jbc.M116.717850

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  41 in total

1.  Cdh1-APC controls axonal growth and patterning in the mammalian brain.

Authors:  Yoshiyuki Konishi; Judith Stegmüller; Takahiko Matsuda; Shirin Bonni; Azad Bonni
Journal:  Science       Date:  2004-01-08       Impact factor: 47.728

2.  APC/C-Cdh1 coordinates neurogenesis and cortical size during development.

Authors:  Maria Delgado-Esteban; Irene García-Higuera; Carolina Maestre; Sergio Moreno; Angeles Almeida
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

3.  SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

Authors:  Hyun-Seok Kim; Athanassios Vassilopoulos; Rui-Hong Wang; Tyler Lahusen; Zhen Xiao; Xiaoling Xu; Cuiling Li; Timothy D Veenstra; Bing Li; Hongtao Yu; Junfang Ji; Xin Wei Wang; Seong-Hoon Park; Yong I Cha; David Gius; Chu-Xia Deng
Journal:  Cancer Cell       Date:  2011-10-18       Impact factor: 31.743

4.  β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3.

Authors:  Jerry J Fong; Brenda L Nguyen; Robert Bridger; Estela E Medrano; Lance Wells; Shujuan Pan; Richard N Sifers
Journal:  J Biol Chem       Date:  2012-02-27       Impact factor: 5.157

5.  Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.

Authors:  C Gieffers; B H Peters; E R Kramer; C G Dotti; J M Peters
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

6.  Regulatory O-GlcNAcylation sites on FoxO1 are yet to be identified.

Authors:  Yann Fardini; Yobana Perez-Cervera; Luc Camoin; Patrick Pagesy; Tony Lefebvre; Tarik Issad
Journal:  Biochem Biophys Res Commun       Date:  2015-05-02       Impact factor: 3.575

Review 7.  The emerging link between O-GlcNAc and Alzheimer disease.

Authors:  Yanping Zhu; Xiaoyang Shan; Scott A Yuzwa; David J Vocadlo
Journal:  J Biol Chem       Date:  2014-10-21       Impact factor: 5.157

8.  Chk2 activation and phosphorylation-dependent oligomerization.

Authors:  Xingzhi Xu; Lyuben M Tsvetkov; David F Stern
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

Review 9.  Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins.

Authors:  Gerald W Hart; Michael P Housley; Chad Slawson
Journal:  Nature       Date:  2007-04-26       Impact factor: 49.962

10.  Atomic structure of the APC/C and its mechanism of protein ubiquitination.

Authors:  Leifu Chang; Ziguo Zhang; Jing Yang; Stephen H McLaughlin; David Barford
Journal:  Nature       Date:  2015-06-15       Impact factor: 49.962
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  6 in total

Review 1.  Too sweet to resist: Control of immune cell function by O-GlcNAcylation.

Authors:  Tristan de Jesus; Sudhanshu Shukla; Parameswaran Ramakrishnan
Journal:  Cell Immunol       Date:  2018-06-02       Impact factor: 4.868

2.  O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes.

Authors:  Caifei Liu; Yingxin Shi; Jie Li; Xuewen Liu; Zhikai Xiahou; Zhongping Tan; Xing Chen; Jing Li
Journal:  J Biol Chem       Date:  2020-04-15       Impact factor: 5.157

Review 3.  Glycosylation Changes in Brain Cancer.

Authors:  Lucas Veillon; Christina Fakih; Hadi Abou-El-Hassan; Firas Kobeissy; Yehia Mechref
Journal:  ACS Chem Neurosci       Date:  2017-11-07       Impact factor: 4.418

Review 4.  Hyperglycemia-Induced Aberrant Cell Proliferation; A Metabolic Challenge Mediated by Protein O-GlcNAc Modification.

Authors:  Tamás Nagy; Viktória Fisi; Dorottya Frank; Emese Kátai; Zsófia Nagy; Attila Miseta
Journal:  Cells       Date:  2019-08-28       Impact factor: 6.600

Review 5.  O-GlcNAc: A Sweetheart of the Cell Cycle and DNA Damage Response.

Authors:  Caifei Liu; Jing Li
Journal:  Front Endocrinol (Lausanne)       Date:  2018-07-30       Impact factor: 5.555

6.  O-Linked N-Acetylglucosamine Transiently Elevates in HeLa Cells during Mitosis.

Authors:  Viktória Fisi; Emese Kátai; József Orbán; Silvia Dossena; Attila Miseta; Tamás Nagy
Journal:  Molecules       Date:  2018-05-26       Impact factor: 4.411
  6 in total

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