Literature DB >> 25333056

Hemorrhagic transformation after cerebral infarction: current concepts and challenges.

Jie Zhang1, Yi Yang1, Huijie Sun1, Yingqi Xing1.   

Abstract

Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke that is especially common after thrombolytic therapy. The risk of HT limits the applicability of tissue plasminogen activator (tPA). Here, we sought to review the rate, classification, predictors, possible mechanism, and clinical outcomes of HT, as well as existing therapeutic approaches, in order to call attention to the current challenges in the treatment of this complication.

Entities:  

Keywords:  Acute ischemic stroke; hemorrhagic transformation (HT)

Year:  2014        PMID： 25333056      PMCID： PMC4200641          DOI： 10.3978/j.issn.2305-5839.2014.08.08

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


  56 in total

1.  Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke.

Authors:  Christian Foerch; Michael T Wunderlich; Florian Dvorak; Marek Humpich; Timo Kahles; Michael Goertler; Jose Alvarez-Sabín; Claus W Wallesch; Carlos A Molina; Helmuth Steinmetz; Matthias Sitzer; Joan Montaner
Journal:  Stroke       Date:  2007-08-02       Impact factor: 7.914

2.  17β-estradiol attenuates breakdown of blood-brain barrier and hemorrhagic transformation induced by tissue plasminogen activator in cerebral ischemia.

Authors:  Mingchang Li; Zhan Zhang; Weiyun Sun; Raymond C Koehler; Judy Huang
Journal:  Neurobiol Dis       Date:  2011-07-18       Impact factor: 5.996

3.  Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis.

Authors:  O Y Bang; J L Saver; D S Liebeskind; S Starkman; P Villablanca; N Salamon; B Buck; L Ali; L Restrepo; F Vinuela; G Duckwiler; R Jahan; T Razinia; B Ovbiagele
Journal:  Neurology       Date:  2006-12-20       Impact factor: 9.910

4.  Low level of low-density lipoprotein cholesterol increases hemorrhagic transformation in large artery atherothrombosis but not in cardioembolism.

Authors:  Beom Joon Kim; Seung-Hoon Lee; Wi-Sun Ryu; Bong Su Kang; Chi Kyung Kim; Byung-Woo Yoon
Journal:  Stroke       Date:  2009-03-12       Impact factor: 7.914

5.  Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group.

Authors: 
Journal:  Stroke       Date:  1997-11       Impact factor: 7.914

6.  Frequency and determinants for hemorrhagic transformation of cerebral infarction.

Authors:  Valeria Terruso; Marco D'Amelio; Norma Di Benedetto; Innocenzo Lupo; Valentina Saia; Giorgia Famoso; Maria Antonietta Mazzola; Paolo Aridon; Caterina Sarno; Paolo Ragonese; Giovanni Savettieri
Journal:  Neuroepidemiology       Date:  2009-07-27       Impact factor: 3.282

7.  The clinical value of antiplatelet therapy for patients with hemorrhage after thrombolysis based on susceptibility-weighted imaging: a prospective pilot study.

Authors:  Jing Lu; Yue-Hua Li; Yong-Dong Li; Ming-Hua Li; Jun-Gong Zhao; Shi-Wen Chen
Journal:  Eur J Radiol       Date:  2012-08-24       Impact factor: 3.528

8.  Acute hyperglycemia and early hemorrhagic transformation in ischemic stroke.

Authors:  Maurizio Paciaroni; Giancarlo Agnelli; Valeria Caso; Francesco Corea; Walter Ageno; Andrea Alberti; Alessia Lanari; Sara Micheli; Luca Bertolani; Michele Venti; Francesco Palmerini; Antonia M R Billeci; Giancarlo Comi; Paolo Previdi; Giorgio Silvestrelli
Journal:  Cerebrovasc Dis       Date:  2009-06-05       Impact factor: 2.762

Review 9.  The role of complement in stroke therapy.

Authors:  Ricardo J Komotar; Grace H Kim; Marc L Otten; Benjamin Hassid; J Mocco; Michael E Sughrue; Robert M Starke; William J Mack; Andrew F Ducruet; Maxwell B Merkow; Matthew C Garrett; E Sander Connolly
Journal:  Adv Exp Med Biol       Date:  2008       Impact factor: 2.622

10.  Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA.

Authors:  Mitsunori Ishiguro; Keisuke Mishiro; Yasuyuki Fujiwara; Huayue Chen; Hiroshi Izuta; Kazuhiro Tsuruma; Masamitsu Shimazawa; Shinichi Yoshimura; Masahiko Satoh; Toru Iwama; Hideaki Hara
Journal:  PLoS One       Date:  2010-12-06       Impact factor: 3.240
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  46 in total

1.  MR image features predicting hemorrhagic transformation in acute cerebral infarction: a multimodal study.

Authors:  Chunming Liu; Zhengchao Dong; Liang Xu; Aiman Khursheed; Longchun Dong; Zhenxing Liu; Jun Yang; Jun Liu
Journal:  Neuroradiology       Date:  2015-08-18       Impact factor: 2.804

2.  Adverse clinical outcomes after dabigatran reversal with idarucizumab to facilitate acute stroke thrombolysis.

Authors:  Felix C Ng; James Bice; Anne Rodda; Matthew Lee-Archer; Douglas E Crompton
Journal:  J Neurol       Date:  2017-02-06       Impact factor: 4.849

Review 3.  Applications and development of permeability imaging in ischemic stroke.

Authors:  Hui Chen; Guangming Zhu; Nan Liu; Ying Li; Yonghong Xia
Journal:  Exp Ther Med       Date:  2018-07-17       Impact factor: 2.447

4.  Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.

Authors:  Audrey P Fan; Ahmed A Khalil; Jochen B Fiebach; Greg Zaharchuk; Arno Villringer; Kersten Villringer; Claudine J Gauthier
Journal:  J Cereb Blood Flow Metab       Date:  2019-02-07       Impact factor: 6.200

Review 5.  Thrombolytic Therapy in Cocaine Users with Ischemic Stroke: A Review of Current Practice.

Authors:  Antonio Siniscalchi; Giovambattista De Sarro; Roberta Pacifici; Ermanno Pisani; Sandro Sanguigni; Luca Gallelli
Journal:  Psychopharmacol Bull       Date:  2019-02-15

Review 6.  Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke.

Authors:  Joshua A Stone; Joshua Z Willey; Salah Keyrouz; James Butera; Ryan A McTaggart; Shawna Cutting; Brian Silver; Bradford Thompson; Karen L Furie; Shadi Yaghi
Journal:  Curr Treat Options Neurol       Date:  2017-01       Impact factor: 3.598

7.  Protective Effects of Autologous Bone Marrow Mononuclear Cells After Administering t-PA in an Embolic Stroke Model.

Authors:  Bing Yang; Weilang Li; Nikunj Satani; Duyen M Nghiem; XiaoPei Xi; Jaroslaw Aronowski; Sean I Savitz
Journal:  Transl Stroke Res       Date:  2017-08-23       Impact factor: 6.829

8.  Thrombosis: Novel nanomedical concepts of diagnosis and treatment.

Authors:  Iwona Cicha
Journal:  World J Cardiol       Date:  2015-08-26

9.  Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction.

Authors:  Y C Chung; A Kruyer; Y Yao; E Feierman; A Richards; S Strickland; E H Norris
Journal:  J Thromb Haemost       Date:  2016-06-13       Impact factor: 5.824

Review 10.  Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets.

Authors:  Na Sun; Richard F Keep; Ya Hua; Guohua Xi
Journal:  Transl Stroke Res       Date:  2016-06-24       Impact factor: 6.829
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