Literature DB >> 25332116

Rhodium-catalyzed NH insertion of pyridyl carbenes derived from pyridotriazoles: a general and efficient approach to 2-picolylamines and imidazo[1,5-a]pyridines.

Yi Shi1, Anton V Gulevich, Vladimir Gevorgyan.   

Abstract

A general and efficient NH insertion reaction of rhodium pyridyl carbenes derived from pyridotriazoles was developed. Various NH-containing compounds, including amides, anilines, enamines, and aliphatic amines, smoothly underwent the NH insertion reaction to afford 2-picolylamine derivatives. The developed transformation was further utilized in a facile one-pot synthesis of imidazo[1,5-a]pyridines.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  annulations; carbenes; heterocycles; rhodium; synthetic methods

Mesh：

Substances：

Year:  2014        PMID： 25332116      PMCID： PMC4262672          DOI： 10.1002/anie.201408335

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  39 in total

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Authors:  Stepan Chuprakov; Sen Wai Kwok; Valery V Fokin
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8.  Arylation of rhodium(II) azavinyl carbenes with boronic acids.

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  6 in total

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5.  Mg3N2-assisted one-pot synthesis of 1,3-disubstituted imidazo[1,5-a]pyridine.

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  6 in total

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