Literature DB >> 25319223

The contribution of deer velvet antler research to the modern biological medicine.

Yu-Shu Huo1, Hong Huo, Jie Zhang.   

Abstract

Deer velvet antler is the only mammal organ which can continuous regenerate. Currently, international scholars are interested in antler that is defined as a perfect regeneration model of neuro, blood vessel, connective tissue, cartilage, and bones. In 1986, we started to study the separation of active protein and peptide of fresh velvet antler using classic biochemical methods. After entering the 21st century, we further investigated the differentiation of antler proteome from different growth periods using advance differential proteomics approach, and unveiled the correlation between the proteome difference and life cycle. The international antler research has entered the stage of molecular biology, and will no doubt have a profound impact on the modern biomedical fields, such as regenerative medicine, organ degeneration and dysplasia, trauma medicine and anti-inflammatory treatment, growth factor research, as well as creation of new medical thinking.

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Year:  2014        PMID: 25319223     DOI: 10.1007/s11655-014-1827-1

Source DB:  PubMed          Journal:  Chin J Integr Med        ISSN: 1672-0415            Impact factor:   1.978


  20 in total

1.  Deer antlerogenic periosteum: a piece of postnatally retained embryonic tissue?

Authors:  C Li; J M Suttie
Journal:  Anat Embryol (Berl)       Date:  2001-11

Review 2.  Regeneration or scarring: an immunologic perspective.

Authors:  Mark Harty; Anton W Neff; Michael W King; Anthony L Mescher
Journal:  Dev Dyn       Date:  2003-02       Impact factor: 3.780

Review 3.  Prometheus's vulture and the stem-cell promise.

Authors:  Nadia Rosenthal
Journal:  N Engl J Med       Date:  2003-07-17       Impact factor: 91.245

4.  [Application of on-line two-dimensional liquid chromatography in comparative proteome analysis of antlers with different growing stages].

Authors:  Liang Gao; Xiaoqiang Qiao; Zhen Liang; Lihua Zhang; Yushu Huo; Yukui Zhang
Journal:  Se Pu       Date:  2010-02

5.  [Purification and characterization of the proliferation of rat osteoblast-like cells UMR-106 from pilose antler].

Authors:  Dong-Yun Lin; Xiao-Nan Huang; Li-Jing Ke; Xiao-Chao Chen; Xiu-Yun Ye; Yu-Shu Huo; Ping-Fan Rao
Journal:  Zhongguo Zhong Yao Za Zhi       Date:  2005-06

6.  Future directions in antler research.

Authors:  R J Goss
Journal:  Anat Rec       Date:  1995-03

7.  A role for retinoic acid in regulating the regeneration of deer antlers.

Authors:  S P Allen; M Maden; J S Price
Journal:  Dev Biol       Date:  2002-11-15       Impact factor: 3.582

8.  Rapid neural growth: calcitonin gene-related peptide and substance P-containing nerves attain exceptional growth rates in regenerating deer antler.

Authors:  C Gray; M Hukkanen; Y T Konttinen; G Terenghi; T R Arnett; S J Jones; G Burnstock; J M Polak
Journal:  Neuroscience       Date:  1992-10       Impact factor: 3.590

9.  Cells cultured from the growing tip of red deer antler express alkaline phosphatase and proliferate in response to insulin-like growth factor-I.

Authors:  J S Price; B O Oyajobi; R O Oreffo; R G Russell
Journal:  J Endocrinol       Date:  1994-11       Impact factor: 4.286

10.  Cells in regenerating deer antler cartilage provide a microenvironment that supports osteoclast differentiation.

Authors:  C Faucheux; S A Nesbitt; M A Horton; J S Price
Journal:  J Exp Biol       Date:  2001-02       Impact factor: 3.312

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  5 in total

1.  Protective effects of Cervus nippon Temminck velvet antler polypeptides against MPP+‑induced cytotoxicity in SH‑SY5Y neuroblastoma cells.

Authors:  Ji-Le Xin; Yang Zhang; Yan Li; Lian-Zhu Zhang; Yong Lin; Lian-Wen Zheng
Journal:  Mol Med Rep       Date:  2017-08-21       Impact factor: 2.952

2.  Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.

Authors:  Wei Zhang; Wenhui Chu; Qingxiu Liu; Dawn Coates; Yudong Shang; Chunyi Li
Journal:  Stem Cell Res Ther       Date:  2018-06-19       Impact factor: 6.832

Review 3.  Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges.

Authors:  Chaochao Yu; Yi Li; Guopeng Chen; Chaoyan Wu; Xiuping Wang; Yingwen Zhang
Journal:  J Zhejiang Univ Sci B       Date:  2022-07-15       Impact factor: 5.552

Review 4.  Health Effects of Peptides Extracted from Deer Antler.

Authors:  Peijun Xia; Dongyue Liu; Yingying Jiao; Zhaoguo Wang; Xi Chen; Shuo Zheng; Jiayuan Fang; Linlin Hao
Journal:  Nutrients       Date:  2022-10-08       Impact factor: 6.706

5.  Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways.

Authors:  Jui-Shu Chang; Hung-Jen Lin; Jeng-Shyan Deng; Wen-Tzu Wu; Shyh-Shyun Huang; Guan-Jhong Huang
Journal:  Evid Based Complement Alternat Med       Date:  2018-01-02       Impact factor: 2.629

  5 in total

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