Literature DB >> 25318851

Modular polyketide synthases (PKSs): a new model fits all?

Alexander Rittner1, Martin Grininger.   

Abstract

Step-by-step to great diversity: With the potential to synthesize multi-millions of bioactive compounds, modular polyketide synthases (PKSs) are of great importance. In this Highlight, new developments in the understanding of the structure and function of these proteins are reviewed.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cryo-EM; fatty acids; multienzymes; natural products; polyketides

Mesh：

Substances：

Year:  2014        PMID： 25318851     DOI： 10.1002/cbic.201402432

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  7 in total

Review 1.  The structural biology of biosynthetic megaenzymes.

Authors:  Kira J Weissman
Journal:  Nat Chem Biol       Date:  2015-09       Impact factor: 15.040

Review 2.  The architectures of iterative type I PKS and FAS.

Authors:  Dominik A Herbst; Craig A Townsend; Timm Maier
Journal:  Nat Prod Rep       Date:  2018-10-17       Impact factor: 13.423

3.  Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.

Authors:  Manuel Fischer; Daniel Rhinow; Zhiwei Zhu; Deryck J Mills; Zongbao K Zhao; Janet Vonck; Martin Grininger
Journal:  Protein Sci       Date:  2015-04-02       Impact factor: 6.725

Review 4.  Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins.

Authors:  Manuel Fischer; Martin Grininger
Journal:  Beilstein J Org Chem       Date:  2017-06-21       Impact factor: 2.883

5.  Solution Structure and Conformational Flexibility of a Polyketide Synthase Module.

Authors:  Maja Klaus; Emanuele Rossini; Andreas Linden; Karthik S Paithankar; Matthias Zeug; Zoya Ignatova; Henning Urlaub; Chaitan Khosla; Jürgen Köfinger; Gerhard Hummer; Martin Grininger
Journal:  JACS Au       Date:  2021-10-18

6.  Site-Specific Labelling of Multidomain Proteins by Amber Codon Suppression.

Authors:  Christina S Heil; Alexander Rittner; Bjarne Goebel; Daniel Beyer; Martin Grininger
Journal:  Sci Rep       Date:  2018-10-05       Impact factor: 4.379

7.  Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase.

Authors:  Martin Sabatini; Santiago Comba; Silvia Altabe; Alejandro I Recio-Balsells; Guillermo R Labadie; Eriko Takano; Hugo Gramajo; Ana Arabolaza
Journal:  FEBS J       Date:  2018-10-25       Impact factor: 5.542
  7 in total

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