Galectin-3 and plasma cytokines in patients with acute myocardial infarction.

OBJECTIVE: To investigate the concentrations of plasma cytokines and Galectin-3 (Gal-3) as inflammatory markers in patients with acute myocardial infarction (AMI).
METHODS: The study population consisted of 29 patients with AMI and 29 healthy control subjects. We measured Gal-3, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) levels in plasma using enzyme-linked immunosorbent assays (ELISAs). We measured levels of C-reactive protein (CRP) via the nephelometric method.
RESULTS: Patients with AMI showed significantly higher plasma Gal-3, TNF-α, and IL-6 levels compared with controls. Gal-3 levels were positively and significantly correlated with plasma IL-6, TNF-α, and CRP levels in the control and patient groups.
CONCLUSION: Our findings suggest that Gal-3 can be a new circulating biomarker of inflammation associated with AMI. Copyright© by the American Society for Clinical Pathology (ASCP).