| Literature DB >> 25313207 |
Seong Mi Moon1, Hye Yun Park1, Byeong-Ho Jeong1, Kyeongman Jeon1, Soo-Youn Lee2, Won-Jung Koh3.
Abstract
We investigated the effects of rifampin and rifabutin on serum itraconazole levels in patients with chronic pulmonary aspergillosis. Serum itraconazole concentrations were significantly lower in patients who received itraconazole with rifampin (median, 0.1 μg/ml; P < 0.001) or rifabutin (median, 0.34 μg/ml; P < 0.001) than those receiving itraconazole alone (median, 5.92 μg/ml). Concomitant use of rifampin or rifabutin and itraconazole should be avoided in patients with chronic pulmonary aspergillosis and coexisting mycobacterial infections.Entities:
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Year: 2014 PMID: 25313207 PMCID: PMC4291413 DOI: 10.1128/AAC.04075-14
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191