Literature DB >> 25309079

Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.

Jiao-Ya Xu1, Zhong-Ping Li1, Li Zhang1, Guang Ji1.   

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually progress to liver inflammation, fibrosis, cirrhosis and even hepatocellular carcinoma. However, the pathogenesis of NAFLD is complex, and no efficient pharmaceutic treatments have yet been established for NAFLD. Accumulating data have shown that the farnesoid X receptor (FXR) plays important roles not only in bile acid metabolism, but also in lipid and carbohydrate homeostasis, inflammatory responses, among others. In this review, we aim to highlight the role of FXR in the pathogenesis and treatment of NAFLD.

Entities:  

Keywords:  Farnesoid X receptor; Lipid metabolism; Mechanism; Non-alcoholic fatty liver disease; Therapy

Mesh：

Substances：

Year:  2014        PMID： 25309079      PMCID： PMC4188900          DOI： 10.3748/wjg.v20.i37.13493

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  86 in total

1.  Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells.

Authors:  Jiang Li; Yifei Zhang; Ramalinga Kuruba; Xiang Gao; Chandrashekhar R Gandhi; Wen Xie; Song Li
Journal:  Mol Pharmacol       Date:  2011-04-21       Impact factor: 4.436

2.  Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study.

Authors:  Xian-Feng Lin; Ke-Qing Shi; Jie You; Wen-Yue Liu; Ying-Wan Luo; Fa-Ling Wu; Yong-Ping Chen; Danny Ka-Ho Wong; Man-Fung Yuen; Ming-Hua Zheng
Journal:  Mol Biol Rep       Date:  2014-01-22       Impact factor: 2.316

Review 3.  The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease.

Authors:  Kyoko Nomura; Toshikazu Yamanouchi
Journal:  J Nutr Biochem       Date:  2011-11-29       Impact factor: 6.048

4.  Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.

Authors:  Tiangang Li; Michelle Matozel; Shannon Boehme; Bo Kong; Lisa-Mari Nilsson; Grace Guo; Ewa Ellis; John Y L Chiang
Journal:  Hepatology       Date:  2011-02-11       Impact factor: 17.425

5.  Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor.

Authors:  Masahiro Nomoto; Masaaki Miyata; Shanai Yin; Yasushi Kurata; Miki Shimada; Kouichi Yoshinari; Frank J Gonzalez; Kokichi Suzuki; Shigeki Shibasaki; Tohru Kurosawa; Yasushi Yamazoe
Journal:  Biol Pharm Bull       Date:  2009-02       Impact factor: 2.233

6.  Activation of farnesoid X receptor induces RECK expression in mouse liver.

Authors:  Xiaomin Peng; Weibin Wu; Bo Zhu; Zhichao Sun; Lingling Ji; Yuanyuan Ruan; Meiling Zhou; Lei Zhou; Jianxin Gu
Journal:  Biochem Biophys Res Commun       Date:  2013-11-28       Impact factor: 3.575

Review 7.  Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis.

Authors:  Giovanni Musso; Roberto Gambino; Maurizio Cassader
Journal:  Prog Lipid Res       Date:  2012-12-01       Impact factor: 16.195

8.  Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response.

Authors:  Yan-Dong Wang; Wei-Dong Chen; Meihua Wang; Donna Yu; Barry M Forman; Wendong Huang
Journal:  Hepatology       Date:  2008-11       Impact factor: 17.425

9.  Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease.

Authors:  Sunder Mudaliar; Robert R Henry; Arun J Sanyal; Linda Morrow; Hanns-Ulrich Marschall; Mark Kipnes; Luciano Adorini; Cathi I Sciacca; Paul Clopton; Erin Castelloe; Paul Dillon; Mark Pruzanski; David Shapiro
Journal:  Gastroenterology       Date:  2013-05-30       Impact factor: 22.682

10.  Dysregulated bile acid synthesis, metabolism and excretion in a high fat-cholesterol diet-induced fibrotic steatohepatitis in rats.

Authors:  Xiaofang Jia; Hisao Naito; Husna Yetti; Hazuki Tamada; Kazuya Kitamori; Yumi Hayashi; Dong Wang; Yukie Yanagiba; Juncai Wang; Katsumi Ikeda; Yukio Yamori; Tamie Nakajima
Journal:  Dig Dis Sci       Date:  2013-07-04       Impact factor: 3.199
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  12 in total

Review 1.  Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus.

Authors:  Giovanni Targher; Amedeo Lonardo; Christopher D Byrne
Journal:  Nat Rev Endocrinol       Date:  2017-12-29       Impact factor: 43.330

Review 2.  Nuclear receptors and nonalcoholic fatty liver disease.

Authors:  Matthew C Cave; Heather B Clair; Josiah E Hardesty; K Cameron Falkner; Wenke Feng; Barbara J Clark; Jennifer Sidey; Hongxue Shi; Bashar A Aqel; Craig J McClain; Russell A Prough
Journal:  Biochim Biophys Acta       Date:  2016-03-04

3.  The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease.

Authors:  Kazuya Okushin; Takeya Tsutsumi; Kenichiro Enooku; Hidetaka Fujinaga; Akira Kado; Junji Shibahara; Masashi Fukayama; Kyoji Moriya; Hiroshi Yotsuyanagi; Kazuhiko Koike
Journal:  J Gastroenterol       Date:  2015-11-25       Impact factor: 7.527

4.  Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.

Authors:  Jingling Jin; Leila Valanejad; Thuy Phuong Nguyen; Kyle Lewis; Mary Wright; Ashley Cast; Lauren Stock; Lubov Timchenko; Nikolai A Timchenko
Journal:  Cell Rep       Date:  2016-06-30       Impact factor: 9.423

Review 5.  Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions.

Authors:  Maria Grazia Clemente; Claudia Mandato; Marco Poeta; Pietro Vajro
Journal:  World J Gastroenterol       Date:  2016-09-28       Impact factor: 5.742

6.  FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity.

Authors:  Sarah J Glastras; Muh Geot Wong; Hui Chen; Jie Zhang; Amgad Zaky; Carol A Pollock; Sonia Saad
Journal:  Nutr Metab (Lond)       Date:  2015-11-14       Impact factor: 4.169

7.  The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.

Authors:  Andrea Ferrigno; Laura Giuseppina Di Pasqua; Clarissa Berardo; Veronica Siciliano; Vittoria Rizzo; Luciano Adorini; Plinio Richelmi; Mariapia Vairetti
Journal:  PLoS One       Date:  2018-01-18       Impact factor: 3.240

8.  A network pharmacology-based approach to explore the effects of Chaihu Shugan powder on a non-alcoholic fatty liver rat model through nuclear receptors.

Authors:  Huan Nie; Yuanjun Deng; Chuiyang Zheng; Maoxing Pan; Jiqian Xie; Yupei Zhang; Qinhe Yang
Journal:  J Cell Mol Med       Date:  2020-03-18       Impact factor: 5.310

Review 9.  Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism.

Authors:  Anita Kumari; Dharam Pal Pathak; Shailendra Asthana
Journal:  Int J Biol Sci       Date:  2020-06-14       Impact factor: 6.580

10.  Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats.

Authors:  Laura Inés Elvira-Torales; Inmaculada Navarro-González; Rocío González-Barrio; Gala Martín-Pozuelo; Guillermo Doménech; Juan Seva; Javier García-Alonso; María Jesús Periago-Castón
Journal:  Nutrients       Date:  2018-09-02       Impact factor: 5.717
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