Literature DB >> 25309014

Extended Fixed Attribute Dynamics Method and an Illustrative Application in Bio-demographic-genetic Analysis on Longevity.

Yi Zeng1.   

Abstract

This chapter presents and discuss the extended Fixed Attributes Dynamics (FAD) method to estimate the independent effect of a genetic variant (or other fixed attribute) in the absence of another relevant genetic variant (or another relevant fixed attribute), the joint effects when both are present and the effects of interactions between them. We present an illustrative application of the extended FAD method for estimating the general, independent and joint effects of the FOXO genotypes on longevity, based on the genotypic data of 760 centenarians from the Chinese Longitudinal Healthy Longevity Survey, and the 1,060 middle-age controls. We also discuss the strengths and limitations of the FAD method.

Entities:  

Keywords:  Bio-demographic analysis; FOXO genes; Fixed Attributes Dynamics method; G×G and G×E interactions; longevity

Year:  2013        PMID： 25309014      PMCID： PMC4191865          DOI： 10.1891/0198-8794.33.217

Source DB:  PubMed          Journal:  Annu Rev Gerontol Geriatr        ISSN： 0198-8794


  9 in total

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Authors:  A I Yashin; G De Benedictis; J W Vaupel; Q Tan; K F Andreev; I A Iachine; M Bonafe; M DeLuca; S Valensin; L Carotenuto; C Franceschi
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

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Authors:  M E Hill
Journal:  Demography       Date:  1999-11

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Authors:  Thomas T Perls; John Wilmoth; Robin Levenson; Maureen Drinkwater; Melissa Cohen; Hazel Bogan; Erin Joyce; Stephanie Brewster; Louis Kunkel; Annibale Puca
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

4.  Effects of FOXO genotypes on longevity: a biodemographic analysis.

Authors:  Yi Zeng; Lingguo Cheng; Huashuai Chen; Huiqing Cao; Elizabeth R Hauser; Yuzhi Liu; Zhenyu Xiao; Qihua Tan; Xiao-Li Tian; James W Vaupel
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-09-30       Impact factor: 6.053

5.  Calculating measures of biological interaction.

Authors:  Tomas Andersson; Lars Alfredsson; Henrik Källberg; Slobodan Zdravkovic; Anders Ahlbom
Journal:  Eur J Epidemiol       Date:  2005       Impact factor: 8.082

6.  Gene-environment interaction: definitions and study designs.

Authors:  R Ottman
Journal:  Prev Med       Date:  1996 Nov-Dec       Impact factor: 4.018

7.  FOXO3A genotype is strongly associated with human longevity.

Authors:  Bradley J Willcox; Timothy A Donlon; Qimei He; Randi Chen; John S Grove; Katsuhiko Yano; Kamal H Masaki; D Craig Willcox; Beatriz Rodriguez; J David Curb
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-02       Impact factor: 11.205

8.  Association of late childbearing with healthy longevity among the oldest-old in China.

Authors:  Zeng Yi; James Vaupel
Journal:  Popul Stud (Camb)       Date:  2004

9.  Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.

Authors:  Yang Li; Wen-Jing Wang; Huiqing Cao; Jiehua Lu; Chong Wu; Fang-Yuan Hu; Jian Guo; Ling Zhao; Fan Yang; Yi-Xin Zhang; Wei Li; Gu-Yan Zheng; Hanbin Cui; Xiaomin Chen; Zhiming Zhu; Hongbo He; Birong Dong; Xianming Mo; Yi Zeng; Xiao-Li Tian
Journal:  Hum Mol Genet       Date:  2009-09-29       Impact factor: 6.150
  9 in total

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