Literature DB >> 20884733

Effects of FOXO genotypes on longevity: a biodemographic analysis.

Yi Zeng1, Lingguo Cheng, Huashuai Chen, Huiqing Cao, Elizabeth R Hauser, Yuzhi Liu, Zhenyu Xiao, Qihua Tan, Xiao-Li Tian, James W Vaupel.   

Abstract

Based on data from 760 centenarians and 1060 middle-age controls (all Han Chinese), this article contributes biodemographic insights and syntheses concerning the magnitude of effects of the FOXO genotypes on longevity. We also estimate independent and joint effects of the genotypes of FOXO1A and FOXO3A genes on long-term survival, considering carrying or not-carrying the minor allele of the single-nucleotide polymorphism of another relevant gene. We found substantial gender differences in the independent effects; positive effects of FOXO3A and negative effects of FOXO1A largely compensate each other if one carries both, although FOXO3A has a stronger impact. Ten-year follow-up cohort analysis shows that at very advanced ages 92-110, adjusted for various confounders, positive effects of FOXO3A on survival remain statistically significant, but no significant effects of FOXO1A alone; G × G interactions between FOXO1A-209 and FOXO3A-310 or FOXO3A-292 decrease survival likelihood by 32%-36% (p < .05); G × E interactions between FOXO1A-209 and regular exercise increase survival likelihood by 31%-32% (p < .05).

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Year:  2010        PMID： 20884733      PMCID： PMC2990269          DOI： 10.1093/gerona/glq156

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  29 in total

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Review 3.  FOXO transcription factors as regulators of immune homeostasis: molecules to die for?

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4.  Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age.

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6.  Resistance exercise, skeletal muscle FOXO3A, and 85-year-old women.

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Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-02-05       Impact factor: 6.053

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  47 in total

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Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-28       Impact factor: 6.053

2.  How genes influence life span: the biodemography of human survival.

Authors:  Anatoliy I Yashin; Deqing Wu; Konstantin G Arbeev; Eric Stallard; Kenneth C Land; Svetlana V Ukraintseva
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3.  Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.

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Journal:  Rejuvenation Res       Date:  2016-02-10       Impact factor: 4.663

4.  Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population.

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Journal:  Oncotarget       Date:  2016-01-05

5.  Predictors of Exceptional Longevity: Effects of Early-Life Childhood Conditions, Midlife Environment and Parental Characteristics.

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Review 6.  Demographics, phenotypic health characteristics and genetic analysis of centenarians in China.

Authors:  Yi Zeng; Qiushi Feng; Danan Gu; James W Vaupel
Journal:  Mech Ageing Dev       Date:  2016-12-28       Impact factor: 5.432

7.  Ovine forkhead box class O 3 (FOXO3) gene variation and its association with lifespan.

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Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-12       Impact factor: 11.205

9.  Towards Deeper Research and Better Policy for Healthy Aging --Using the Unique Data of Chinese Longitudinal Healthy Longevity Survey.

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Journal:  China Economic J       Date:  2012

10.  Health consequences of familial longevity influence among the Chinese elderly.

Authors:  Yi Zeng; Huashuai Chen; Xiaoming Shi; Zhaoxue Yin; Ze Yang; Jun Gu; Dan Blazer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-10-12       Impact factor: 6.053
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