Literature DB >> 25306924

An ESR and DFT study of hydration of the 2'-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate.

Lidia Chomicz1, Alex Petrovici, Ian Archbold, Amitava Adhikary, Anil Kumar, Michael D Sevilla, Janusz Rak.   

Abstract

The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2'-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical.

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Year:  2014        PMID： 25306924      PMCID： PMC4213299          DOI： 10.1039/c4cc07089e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  20 in total

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Journal:  Cancer Treat Rev       Date:  1976-12       Impact factor: 12.111

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Journal:  Radiother Oncol       Date:  1998-03       Impact factor: 6.280

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Journal:  Radiat Res       Date:  1965-12       Impact factor: 2.841

5.  Enhancement of X ray induced DNA damage by pre-treatment with halogenated pyrimidine analogs.

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Journal:  Int J Radiat Oncol Biol Phys       Date:  1987-05       Impact factor: 7.038

6.  Electron-induced elimination of the bromide anion from brominated nucleobases. A computational study.

Authors:  Lidia Chomicz; Janusz Rak; Piotr Storoniak
Journal:  J Phys Chem B       Date:  2012-05-03       Impact factor: 2.991

7.  Photochemistry and reactivity of the phenyl radical-water system: a matrix isolation and computational study.

Authors:  Artur Mardyukov; Rachel Crespo-Otero; Elsa Sanchez-Garcia; Wolfram Sander
Journal:  Chemistry       Date:  2010-08-02       Impact factor: 5.236

8.  First-in-human phase 0 trial of oral 5-iodo-2-pyrimidinone-2'-deoxyribose in patients with advanced malignancies.

Authors:  Shivaani Kummar; Larry Anderson; Kimberly Hill; Eva Majerova; Deborah Allen; Yvonne Horneffer; S Percy Ivy; Larry Rubinstein; Pamela Harris; James H Doroshow; Jerry M Collins
Journal:  Clin Cancer Res       Date:  2013-02-12       Impact factor: 12.531

9.  5-Bromodeoxyuridine radiosensitization: conformation-dependent DNA damage.

Authors:  Marie-Eve Dextraze; J Richard Wagner; Darel J Hunting
Journal:  Biochemistry       Date:  2007-07-13       Impact factor: 3.162

10.  Single-strand-specific radiosensitization of DNA by bromodeoxyuridine.

Authors:  S Cecchini; S Girouard; M A Huels; L Sanche; D J Hunting
Journal:  Radiat Res       Date:  2004-12       Impact factor: 2.841
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  4 in total

1.  5-Thiocyanato-2'-deoxyuridine as a possible radiosensitizer: electron-induced formation of uracil-C5-thiyl radical and its dimerization.

Authors:  Magdalena Zdrowowicz; Lidia Chomicz; Michał Żyndul; Paweł Wityk; Janusz Rak; Tyler J Wiegand; Cameron G Hanson; Amitava Adhikary; Michael D Sevilla
Journal:  Phys Chem Chem Phys       Date:  2015-07-14       Impact factor: 3.676

2.  Cytosine Iminyl Radical (cytN•) Formation via Electron-Induced Debromination of 5-Bromocytosine: A DFT and Gaussian 4 Study.

Authors:  Anil Kumar; Michael D Sevilla
Journal:  J Phys Chem A       Date:  2017-06-16       Impact factor: 2.781

3.  Quasi-Free Electron-Mediated Radiation Sensitization by C5-Halopyrimidines.

Authors:  Jun Ma; Teseer Bahry; Sergey A Denisov; Amitava Adhikary; Mehran Mostafavi
Journal:  J Phys Chem A       Date:  2021-09-02       Impact factor: 2.944

4.  Electron Attachment to 5-Fluorouracil: The Role of Hydrogen Fluoride in Dissociation Chemistry.

Authors:  Eugene Arthur-Baidoo; Gabriel Schöpfer; Milan Ončák; Lidia Chomicz-Mańka; Janusz Rak; Stephan Denifl
Journal:  Int J Mol Sci       Date:  2022-07-28       Impact factor: 6.208
  4 in total

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