AIM: There were several studies that have researched the associations between lysyl oxidase-like 1 (LOXL1) gene polymorphism and the susceptibility to exfoliation syndrome (XFS)/exfoliation glaucoma (XFG), but results have been inconclusive. MATERIALS AND METHODS: A meta-analysis was performed for deriving more exact estimation of the relationship. Twenty-five studies were selected for studying rs1048661 and rs3825942. Sixteen studies were selected for studying rs2165241. RESULTS: Single nucleotide polymorphism (SNP) rs1048661 was found to be associated with XFS/XFG, but the risk allele in white populations was found to be G, as opposite to the T allele in Japanese, Chinese, and Korean populations. The SNP rs3825942 was significantly associated with XFS in this black South African population. However, the AA genotype of rs3825942 confers XFS risk in this population, as opposed to the GG genotype described in all other populations. SNP rs2165241 was found to be associated with XFS/XFG, but the risk allele in white populations was found to be T, as opposite to the "C" allele in Japanese and Korean populations. CONCLUSIONS: Our meta-analysis indicates that rs1048661 ("G" alleles) had weak association with XFG/XFS; rs3825942 ("G" alleles) had strongly association with XFG/XFS; and rs2165241("T" alleles) had significant risk with XFG/XFS in some ethnicity.
AIM: There were several studies that have researched the associations between lysyl oxidase-like 1 (LOXL1) gene polymorphism and the susceptibility to exfoliation syndrome (XFS)/exfoliation glaucoma (XFG), but results have been inconclusive. MATERIALS AND METHODS: A meta-analysis was performed for deriving more exact estimation of the relationship. Twenty-five studies were selected for studying rs1048661 and rs3825942. Sixteen studies were selected for studying rs2165241. RESULTS: Single nucleotide polymorphism (SNP) rs1048661 was found to be associated with XFS/XFG, but the risk allele in white populations was found to be G, as opposite to the T allele in Japanese, Chinese, and Korean populations. The SNP rs3825942 was significantly associated with XFS in this black South African population. However, the AA genotype of rs3825942 confers XFS risk in this population, as opposed to the GG genotype described in all other populations. SNP rs2165241 was found to be associated with XFS/XFG, but the risk allele in white populations was found to be T, as opposite to the "C" allele in Japanese and Korean populations. CONCLUSIONS: Our meta-analysis indicates that rs1048661 ("G" alleles) had weak association with XFG/XFS; rs3825942 ("G" alleles) had strongly association with XFG/XFS; and rs2165241("T" alleles) had significant risk with XFG/XFS in some ethnicity.
Authors: C C Cousins; J H Kang; C Bovee; J Wang; S H Greenstein; A Turalba; L Q Shen; S Brauner; T Boumenna; S Blum; H Levkovitch-Verbin; R Ritch; J L Wiggs; P A Knepper; L R Pasquale Journal: Eye (Lond) Date: 2017-01-13 Impact factor: 3.775
Authors: Bao J Fan; Louis R Pasquale; Jae H Kang; Hani Levkovitch-Verbin; Jonathan L Haines; Janey L Wiggs Journal: Exp Eye Res Date: 2015-08-10 Impact factor: 3.467
Authors: Brian M Besch; Karen Curtin; Robert Ritch; R Rand Allingham; Barbara M Wirostko Journal: JAMA Ophthalmol Date: 2018-12-01 Impact factor: 7.389
Authors: Daniel Berner; Ursula Hoja; Matthias Zenkel; James Julian Ross; Steffen Uebe; Daniela Paoli; Paolo Frezzotti; Robyn M Rautenbach; Ari Ziskind; Susan E Williams; Trevor R Carmichael; Michele Ramsay; Fotis Topouzis; Anthi Chatzikyriakidou; Alexandros Lambropoulos; Periasamy Sundaresan; Humaira Ayub; Farah Akhtar; Raheel Qamar; Juan C Zenteno; Marisa Cruz-Aguilar; Yury S Astakhov; Michael Dubina; Janey Wiggs; Mineo Ozaki; Friedrich E Kruse; Tin Aung; André Reis; Chiea Chuen Khor; Francesca Pasutto; Ursula Schlötzer-Schrehardt Journal: Hum Mol Genet Date: 2019-08-01 Impact factor: 6.150