Hanspal Singh1, Pushparaja Shetty2, Sreelatha S V3, Madvikha Patidar4. 1. Senior Resident, Department of Oral Pathology & Microbiology, Maulana Azad Institute of Dental Sciences , New Delhi, India . 2. Professor, Head of the Department, Department of Oral Pathology & Microbiology, A.B. Shetty Memorial Institute of Dental Sciences , Mangalore, Karnataka, India . 3. Reader, Department of Oral Pathology & Microbiology, A.B. Shetty Memorial Institute of Dental Sciences , Mangalore, Karnataka, India . 4. Senior lecturer, Babu Banarasi Das college of Dental Sciences , Lucknow, Uttar Pradesh, India .
Abstract
OBJECTIVE: To estimate and Compare of salivary antioxidant level {Uric acid (UA), Glutathione S Transferase (GST) and Superoxide dismutase (SOD)} between healthy control and study group (oral squamous cell carcinoma patients).Further comparison of sub division of study group on the basis of clinical staging and histological grading. MATERIALS AND METHODS: The study group consists of 50 cases of squamous cell carcinoma and 50 healthy patients. These parameters were estimated by spectrophotometer. The biochemical values of this study were subjected to statistical analysis i.e. Independent t-test, ANOVA and Tukey test. RESULT: UA suggested statistically significant changes in saliva of clinical staging and histological grading of oral squamous cell carcinoma (SCC) patients. Salivary SOD level between well to poorly differentiated SCC showed a progressive increase although it is not statistically significant. CONCLUSION: Salivary analysis of antioxidant is simple, non-invasive technique which may be useful as diagnostic, prognostic and therapeutic marker.
OBJECTIVE: To estimate and Compare of salivary antioxidant level {Uric acid (UA), Glutathione S Transferase (GST) and Superoxide dismutase (SOD)} between healthy control and study group (oral squamous cell carcinomapatients).Further comparison of sub division of study group on the basis of clinical staging and histological grading. MATERIALS AND METHODS: The study group consists of 50 cases of squamous cell carcinoma and 50 healthy patients. These parameters were estimated by spectrophotometer. The biochemical values of this study were subjected to statistical analysis i.e. Independent t-test, ANOVA and Tukey test. RESULT: UA suggested statistically significant changes in saliva of clinical staging and histological grading of oral squamous cell carcinoma (SCC) patients. Salivary SOD level between well to poorly differentiated SCC showed a progressive increase although it is not statistically significant. CONCLUSION: Salivary analysis of antioxidant is simple, non-invasive technique which may be useful as diagnostic, prognostic and therapeutic marker.
Authors: Rafael M Nagler; Ifat Klein; Nataly Zarzhevsky; Noam Drigues; Abraham Z Reznick Journal: Free Radic Biol Med Date: 2002-02-01 Impact factor: 7.376
Authors: Luciana S Marocchio; Joelma Lima; Felipe F Sperandio; Luciana Corrêa; Suzana O M de Sousa Journal: J Oral Sci Date: 2010-06 Impact factor: 1.556