Nazli Khatib1, Shilpa Gaidhane2, Abhay M Gaidhane3, Mahanaaz Khatib4, Padam Simkhada5, Dilip Gode6, Quazi Syed Zahiruddin7. 1. Associate Professor, Department of Physiology, Datta Meghe Institute of Medical Sciences , Sawangi (Meghe), Wardha, India . 2. Assistant Professor, Department of Community Medicine, Datta Meghe Institute of Medical Sciences , Sawangi (Meghe), Wardha, India . 3. Professor, Department of Community Medicine, J N Medical College, Datta Meghe Institute of Medical Sciences , Sawangi (Meghe), Wardha, India . 4. Pharmacovigilance Co-ordinator, i3global , Pune Maharashtra, India . 5. Senior Lecturer, International Health School of Health and Related Research (ScHARR),University of Sheffield , UK . 6. Vice Chancellor, Datta Meghe Institute of Medical Sciences , Sawangi (Meghe), Wardha, India . 7. Associate Dean, Professor, Department of Community Medicine, Datta Meghe Institute of Medical Sciences , Sawangi (Meghe), Wardha, India .
Abstract
BACKGROUND: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis. OBJECTIVE: This review highlights the interaction of ghrelin with GHRH and somatostatin to regulate the secretion of GH and intends to explore the possible physiological role of the ghrelin-pituitary-GH axis linkage system. OBSERVATION: Ghrelin is highly conserved among species and is classified into octanoylated (C8:0), decanoylated (C10:0), decenoylated (C10:1) and nonacylated,ghrelin. Acylated ghrelin is the major active form of human ghrelin. The primary production site of ghrelin is the stomach, and it interacts with stomach ghrelin as well as hypothalamic GHRH and somatostatin in the regulation of pituitary GH secretion. Ghrelin stimulate GH release through the GHS receptor to increase intracellular Ca2+ ([Ca2+] levels via IP3 signal transduction pathway. Ghrelin is a specific endogenous ligand for the GHS receptor and provides a definitive proof of the occurance of a GHS-GHS receptor signalling system in the regulation of GH secretion. CONCLUSION: Studies suggests that ghrelin is a powerful pharmacological agent that exerts a potent, time-dependent stimulation of pulsatile secretion of GH.
BACKGROUND:Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis. OBJECTIVE: This review highlights the interaction of ghrelin with GHRH and somatostatin to regulate the secretion of GH and intends to explore the possible physiological role of the ghrelin-pituitary-GH axis linkage system. OBSERVATION: Ghrelin is highly conserved among species and is classified into octanoylated (C8:0), decanoylated (C10:0), decenoylated (C10:1) and nonacylated,ghrelin. Acylated ghrelin is the major active form of humanghrelin. The primary production site of ghrelin is the stomach, and it interacts with stomach ghrelin as well as hypothalamic GHRH and somatostatin in the regulation of pituitary GH secretion. Ghrelin stimulate GH release through the GHS receptor to increase intracellular Ca2+ ([Ca2+] levels via IP3 signal transduction pathway. Ghrelin is a specific endogenous ligand for the GHS receptor and provides a definitive proof of the occurance of a GHS-GHS receptor signalling system in the regulation of GH secretion. CONCLUSION: Studies suggests that ghrelin is a powerful pharmacological agent that exerts a potent, time-dependent stimulation of pulsatile secretion of GH.
Authors: M Moussouttas; P Fayad; M Rosenblatt; M Hashimoto; J Pollak; K Henderson; T Y Ma; R I White Journal: Neurology Date: 2000-10-10 Impact factor: 9.910
Authors: F Strasser; T A Lutz; M T Maeder; B Thuerlimann; D Bueche; M Tschöp; K Kaufmann; B Holst; M Brändle; R von Moos; R Demmer; T Cerny Journal: Br J Cancer Date: 2008-01-08 Impact factor: 7.640
Authors: Inge Seim; Penny L Jeffery; Laura de Amorim; Carina M Walpole; Jenny Fung; Eliza J Whiteside; Rohan Lourie; Adrian C Herington; Lisa K Chopin Journal: Reprod Biol Endocrinol Date: 2013-07-23 Impact factor: 5.211
Authors: Frederick Wasinski; Franco Barrile; João A B Pedroso; Paula G F Quaresma; Willian O Dos Santos; Edward O List; John J Kopchick; Mario Perelló; Jose Donato Journal: Endocrinology Date: 2021-07-01 Impact factor: 4.736