Literature DB >> 25301080

The neurobiological bases of memory formation: from physiological conditions to psychopathology.

Reto Bisaz1, Alessio Travaglia, Cristina M Alberini.   

Abstract

The formation of long-term memories is a function necessary for an adaptive survival. In the last two decades, great progress has been made in the understanding of the biological bases of memory formation. The identification of mechanisms necessary for memory consolidation and reconsolidation, the processes by which the posttraining and postretrieval fragile memory traces become stronger and insensitive to disruption, has indicated new approaches for investigating and treating psychopathologies. In this review, we will discuss some key biological mechanisms found to be critical for memory consolidation and strengthening, the role/s and mechanisms of memory reconsolidation, and how the interference with consolidation and/or reconsolidation can modulate the retention and/or storage of memories that are linked to psychopathologies.
© 2014 S. Karger AG, Basel.

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Year:  2014        PMID: 25301080      PMCID: PMC4246028          DOI: 10.1159/000363702

Source DB:  PubMed          Journal:  Psychopathology        ISSN: 0254-4962            Impact factor:   1.944


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