Literature DB >> 25298198

Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.

Rachel H L H Rueli1, Arlene C Parubrub1, Andrea S T Dewing1, Ann C Hashimoto1, Miyoko T Bellinger1, Edwin J Weeber2, Jane H Uyehara-Lock3, Lon R White4, Marla J Berry1, Frederick P Bellinger1.   

Abstract

Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.

Entities:  

Keywords:  Alzheimer's disease; Sepp1; cerebrospinal fluid; choroid plexus; selenium; selenoprotein P; selenoproteins

Mesh：

Substances：

Year:  2015        PMID： 25298198      PMCID： PMC4419036          DOI： 10.3233/JAD-141755

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  19 in total

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