Literature DB >> 25297007

Oridonin suppress cell migration via regulation of nonmuscle myosin IIA.

Yin-Chao Li1, Mo-Ran Sun1, Yi-Hong Zhao1, Xian-Zu Fu1, Hai-Wei Xu2, Ji-Feng Liu3.   

Abstract

Oridonin, which is isolated from Chinese herb Rabdosia rubescens (Hemsl.) Hara, has been implicated in regulation of tumor cell migration and invasion. In this study, treatment with oridonin enhanced the phosphorylation of myosin regulatory light chain (T18/S19) that regulates the ATPase activity of myosin IIA. Meanwhile, stress fibers were significantly more prominent after oridonin incubation, which impaired cell migration in transwell migration assays. All of these effects may be caused by the decreased interaction between myosin IIA and myosin phosphatase complex, but not kinases. Our data provide clear evidence of this novel pharmacological function for oridonin in treating cancer cell migration.

Entities:  

Keywords:  Migration; Myosin IIA; Oridonin; Phosphatase complex; Regulatory light chain

Year:  2014        PMID： 25297007      PMCID： PMC4846644          DOI： 10.1007/s10616-014-9790-4

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  34 in total

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Review 7.  Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics.

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1.  Structural modification of oridonin via DAST induced rearrangement.

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3.  Bioactive Ent-Kaurane Diterpenes Oridonin and Irudonin Prevent Cancer Cells Migration by Interacting with the Actin Cytoskeleton Controller Ezrin.

Authors:  Valentina Pagliara; Giuliana Donadio; Nunziatina De Tommasi; Giuseppina Amodio; Paolo Remondelli; Ornella Moltedo; Fabrizio Dal Piaz
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Review 4.  Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity.

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  4 in total

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