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Literature DB >> 12778124

Rocks: multifunctional kinases in cell behaviour.

Abstract

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.

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Year: 2003 PMID： 12778124 DOI： 10.1038/nrm1128

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

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Cited

682 in total

1. Topical Rho-Associated Kinase Inhibitor, Y27632, Accelerates Corneal Endothelial Regeneration in a Canine Cryoinjury Model.

Authors: Hidetaka Miyagi; Soohyun Kim; Jennifer Li; Christopher J Murphy; Sara M Thomasy
Journal: Cornea Date: 2019-03 Impact factor: 2.651

2. Platelet senescence and phosphatidylserine exposure.

Authors: Swapan Kumar Dasgupta; Eduardo Rios Argaiz; Jose Emmanel Chedid Mercado; Hector Omar Elizondo Maul; Jorge Garza; Ana Bety Enriquez; Hanan Abdel-Monem; Anthony Prakasam; Michael Andreeff; Perumal Thiagarajan
Journal: Transfusion Date: 2010-10-04 Impact factor: 3.157

Review 3. The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis.

Authors: Rachel S Knipe; Andrew M Tager; James K Liao
Journal: Pharmacol Rev Date: 2015 Impact factor: 25.468

4. The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

Authors: Hideaki Naoe; Kimi Araki; Osamu Nagano; Yusuke Kobayashi; Jo Ishizawa; Tatsuyuki Chiyoda; Takatsune Shimizu; Ken-ichi Yamamura; Yutaka Sasaki; Hideyuki Saya; Shinji Kuninaka
Journal: Mol Cell Biol Date: 2010-06-07 Impact factor: 4.272

5. The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish.

Authors: Guangliang Wang; Adam B Cadwallader; Duck Soo Jang; Michael Tsang; H Joseph Yost; Jeffrey D Amack
Journal: Development Date: 2010-11-23 Impact factor: 6.868

6. ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells.

Authors: David A Claassen; Michelle M Desler; Angie Rizzino
Journal: Mol Reprod Dev Date: 2009-08 Impact factor: 2.609

Rocks: multifunctional kinases in cell behaviour.

1. Topical Rho-Associated Kinase Inhibitor, Y27632, Accelerates Corneal Endothelial Regeneration in a Canine Cryoinjury Model.

2. Platelet senescence and phosphatidylserine exposure.

Review 3. The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis.

4. The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

5. The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish.

6. ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells.

7. Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.

8. Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

9. Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells.

Review 10. Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling.