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Literature DB >> 25295784

Muscle over mind.

Abstract

Depression is associated with elevated kynurenine levels, a tryptophan metabolite generated under stress and inflammatory conditions. Agudelo et al. (2014) now reveal how PGC-1α1 overexpression in muscle mimics anti-depressant effects of exercise by promoting kynurenine aminotransferase expression, likely preventing kynurenine from crossing the blood brain barrier to disrupt neural plasticity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25295784 PMCID： PMC6016023 DOI： 10.1016/j.cmet.2014.09.012

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

10 in total

Review 1. Emerging role of glutamate in the pathophysiology of major depressive disorder.

Authors: Kenji Hashimoto
Journal: Brain Res Rev Date: 2009-05-28

2. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Authors: Leandro Z Agudelo; Teresa Femenía; Funda Orhan; Margareta Porsmyr-Palmertz; Michel Goiny; Vicente Martinez-Redondo; Jorge C Correia; Manizheh Izadi; Maria Bhat; Ina Schuppe-Koistinen; Amanda T Pettersson; Duarte M S Ferreira; Anna Krook; Romain Barres; Juleen R Zierath; Sophie Erhardt; Maria Lindskog; Jorge L Ruas
Journal: Cell Date: 2014-09-25 Impact factor: 41.582

3. AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.

Authors: Brennan K Smith; Kazutaka Mukai; James S Lally; Amy C Maher; Brendon J Gurd; George J F Heigenhauser; Lawrence L Spriet; Graham P Holloway
Journal: J Physiol Date: 2013-01-07 Impact factor: 5.182

4. Endurance factors improve hippocampal neurogenesis and spatial memory in mice.

Authors: Tali Kobilo; Chunyan Yuan; Henriette van Praag
Journal: Learn Mem Date: 2011-01-18 Impact factor: 2.460

Review 5. Kynurenines in the mammalian brain: when physiology meets pathology.

Authors: Robert Schwarcz; John P Bruno; Paul J Muchowski; Hui-Qiu Wu
Journal: Nat Rev Neurosci Date: 2012-07 Impact factor: 34.870

6. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials.

Authors: D A Lawlor; S W Hopker
Journal: BMJ Date: 2001-03-31

Review 7. PGC-1 coactivators and skeletal muscle adaptations in health and disease.

Authors: Zolt Arany
Journal: Curr Opin Genet Dev Date: 2008-09-07 Impact factor: 5.578

Review 8. Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways.

Authors: Gregory Oxenkrug
Journal: Mol Neurobiol Date: 2013-06-28 Impact factor: 5.590

9. AMPK and PPARdelta agonists are exercise mimetics.

Authors: Vihang A Narkar; Michael Downes; Ruth T Yu; Emi Embler; Yong-Xu Wang; Ester Banayo; Maria M Mihaylova; Michael C Nelson; Yuhua Zou; Henry Juguilon; Heonjoong Kang; Reuben J Shaw; Ronald M Evans
Journal: Cell Date: 2008-07-31 Impact factor: 41.582

10. AMPK agonist AICAR improves cognition and motor coordination in young and aged mice.

Authors: Tali Kobilo; Davide Guerrieri; Yongqing Zhang; Sarah C Collica; Kevin G Becker; Henriette van Praag
Journal: Learn Mem Date: 2014-01-17 Impact factor: 2.460

10 in total

11 in total

Review 1. The Potential Mechanisms of Exercise-induced Cognitive Protection: A Literature Review.

Authors: Jennifer E Norman; Jennifer Rutkowsky; Sue Bodine; John C Rutledge
Journal: Curr Pharm Des Date: 2018 Impact factor: 3.116

2. The Magic of Movement; the Potential of Exercise to Improve Cognition.

Authors: Iris E Sommer; René S Kahn
Journal: Schizophr Bull Date: 2015-03-23 Impact factor: 9.306

Review 3. Revisiting the Stress Concept: Implications for Affective Disorders.

Authors: Bruce S McEwen; Huda Akil
Journal: J Neurosci Date: 2020-01-02 Impact factor: 6.167

4. State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.

Authors: Kaleen M Lavin; Paul M Coen; Liliana C Baptista; Margaret B Bell; Devin Drummer; Sara A Harper; Manoel E Lixandrão; Jeremy S McAdam; Samia M O'Bryan; Sofhia Ramos; Lisa M Roberts; Rick B Vega; Bret H Goodpaster; Marcas M Bamman; Thomas W Buford
Journal: Compr Physiol Date: 2022-03-09 Impact factor: 8.915

Review 5. Role of physical and mental training in brain network configuration.

Authors: Philip P Foster
Journal: Front Aging Neurosci Date: 2015-06-23 Impact factor: 5.750

Review 6. Can physical exercise in old age improve memory and hippocampal function?

Authors: Emrah Duzel; Henriette van Praag; Michael Sendtner
Journal: Brain Date: 2016-02-11 Impact factor: 13.501

7. The current state of physical activity and exercise programs in German-speaking, Swiss psychiatric hospitals: results from a brief online survey.

Authors: Serge Brand; Flora Colledge; Nadja Beeler; Uwe Pühse; Nadeem Kalak; Dena Sadeghi Bahmani; Thorsten Mikoteit; Edith Holsboer-Trachsler; Markus Gerber
Journal: Neuropsychiatr Dis Treat Date: 2016-06-03 Impact factor: 2.570