Literature DB >> 25290463

Cognitive control network function in alcohol use disorder before and during treatment with lorazepam.

Claire E Wilcox1, Andrew R Mayer, Michael P Bogenschutz, Josef Ling, Charlene Dekonenko, Heather Cumbo.   

Abstract

Individuals with alcohol use disorders (AUDs) have deficits in cognitive control, but how they change with treatment is unclear. Seven patients with AUD and anxiety from an open-label trial of disulfiram plus lorazepam performed a multisensory Stroop task during fMRI (both pre and post initiation of treatment), and were compared to nine healthy controls (HCs) (n = 16; Albuquerque, NM; years 2009-2012). Evoked BOLD signal and resting state functional connectivity were compared (HC vs. AUD; Scan 1 vs. Scan 2). AUD demonstrated hyperactivity and altered connectivity in the cognitive control network compared to HC, but treatment did not normalize function.

Entities:  

Keywords:  Stroop; alcohol dependence; alcohol use disorder; benzodiazepine; cognitive control; connectivity; fMRI; lorazepam; treatment

Mesh:

Substances:

Year:  2014        PMID: 25290463      PMCID: PMC4418428          DOI: 10.3109/10826084.2014.957771

Source DB:  PubMed          Journal:  Subst Use Misuse        ISSN: 1082-6084            Impact factor:   2.164


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