| Literature DB >> 25290463 |
Claire E Wilcox1, Andrew R Mayer, Michael P Bogenschutz, Josef Ling, Charlene Dekonenko, Heather Cumbo.
Abstract
Individuals with alcohol use disorders (AUDs) have deficits in cognitive control, but how they change with treatment is unclear. Seven patients with AUD and anxiety from an open-label trial of disulfiram plus lorazepam performed a multisensory Stroop task during fMRI (both pre and post initiation of treatment), and were compared to nine healthy controls (HCs) (n = 16; Albuquerque, NM; years 2009-2012). Evoked BOLD signal and resting state functional connectivity were compared (HC vs. AUD; Scan 1 vs. Scan 2). AUD demonstrated hyperactivity and altered connectivity in the cognitive control network compared to HC, but treatment did not normalize function.Entities:
Keywords: Stroop; alcohol dependence; alcohol use disorder; benzodiazepine; cognitive control; connectivity; fMRI; lorazepam; treatment
Mesh:
Substances:
Year: 2014 PMID: 25290463 PMCID: PMC4418428 DOI: 10.3109/10826084.2014.957771
Source DB: PubMed Journal: Subst Use Misuse ISSN: 1082-6084 Impact factor: 2.164