Literature DB >> 25288306

Brd4 is on the move during inflammation.

Yali Xu1, Christopher R Vakoc2.   

Abstract

Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  BET bromodomain; Brd4; JQ1; NF-kB; enhancer; inflammation; p65; super-enhancer

Mesh：

Substances：

Year:  2014        PMID： 25288306      PMCID： PMC4252248          DOI： 10.1016/j.tcb.2014.09.005

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  10 in total

1.  Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.

Authors:  Bo Huang; Xiao-Dong Yang; Ming-Ming Zhou; Keiko Ozato; Lin-Feng Chen
Journal:  Mol Cell Biol       Date:  2008-12-22       Impact factor: 4.272

2.  NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.

Authors:  Jonathan D Brown; Charles Y Lin; Qiong Duan; Gabriel Griffin; Alexander Federation; Ronald M Paranal; Steven Bair; Gail Newton; Andrew Lichtman; Andrew Kung; Tianlun Yang; Hong Wang; Francis W Luscinskas; Kevin Croce; James E Bradner; Jorge Plutzky
Journal:  Mol Cell       Date:  2014-09-25       Impact factor: 17.970

Review 3.  Transcription factors: from enhancer binding to developmental control.

Authors:  François Spitz; Eileen E M Furlong
Journal:  Nat Rev Genet       Date:  2012-08-07       Impact factor: 53.242

4.  Latent enhancers activated by stimulation in differentiated cells.

Authors:  Renato Ostuni; Viviana Piccolo; Iros Barozzi; Sara Polletti; Alberto Termanini; Silvia Bonifacio; Alessia Curina; Elena Prosperini; Serena Ghisletti; Gioacchino Natoli
Journal:  Cell       Date:  2013-01-17       Impact factor: 41.582

Review 5.  Enhancer biology and enhanceropathies.

Authors:  Edwin Smith; Ali Shilatifard
Journal:  Nat Struct Mol Biol       Date:  2014-03       Impact factor: 15.369

6.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

Authors:  Sven Heinz; Christopher Benner; Nathanael Spann; Eric Bertolino; Yin C Lin; Peter Laslo; Jason X Cheng; Cornelis Murre; Harinder Singh; Christopher K Glass
Journal:  Mol Cell       Date:  2010-05-28       Impact factor: 17.970

7.  Suppression of inflammation by a synthetic histone mimic.

Authors:  Edwige Nicodeme; Kate L Jeffrey; Uwe Schaefer; Soren Beinke; Scott Dewell; Chun-Wa Chung; Rohit Chandwani; Ivan Marazzi; Paul Wilson; Hervé Coste; Julia White; Jorge Kirilovsky; Charles M Rice; Jose M Lora; Rab K Prinjha; Kevin Lee; Alexander Tarakhovsky
Journal:  Nature       Date:  2010-11-10       Impact factor: 49.962

8.  Selective inhibition of tumor oncogenes by disruption of super-enhancers.

Authors:  Jakob Lovén; Heather A Hoke; Charles Y Lin; Ashley Lau; David A Orlando; Christopher R Vakoc; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

9.  Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

Authors:  Minna U Kaikkonen; Nathanael J Spann; Sven Heinz; Casey E Romanoski; Karmel A Allison; Joshua D Stender; Hyun B Chun; David F Tough; Rab K Prinjha; Christopher Benner; Christopher K Glass
Journal:  Mol Cell       Date:  2013-08-08       Impact factor: 17.970

10.  A high-resolution map of the three-dimensional chromatin interactome in human cells.

Authors:  Fulai Jin; Yan Li; Jesse R Dixon; Siddarth Selvaraj; Zhen Ye; Ah Young Lee; Chia-An Yen; Anthony D Schmitt; Celso A Espinoza; Bing Ren
Journal:  Nature       Date:  2013-10-20       Impact factor: 49.962
  10 in total
  14 in total

1.  Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage.

Authors:  Beatriz Suarez-Alvarez; José Luis Morgado-Pascual; Sandra Rayego-Mateos; Ramon M Rodriguez; Raul Rodrigues-Diez; Pablo Cannata-Ortiz; Ana B Sanz; Jesus Egido; Pierre-Louis Tharaux; Alberto Ortiz; Carlos Lopez-Larrea; Marta Ruiz-Ortega
Journal:  J Am Soc Nephrol       Date:  2016-07-19       Impact factor: 10.121

Review 2.  Epigenetic regulation of cardiac fibrosis.

Authors:  Matthew S Stratton; Timothy A McKinsey
Journal:  J Mol Cell Cardiol       Date:  2016-02-12       Impact factor: 5.000

3.  The next-generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner.

Authors:  Dan A Erkes; Conroy O Field; Claudia Capparelli; Manoela Tiago; Timothy J Purwin; Inna Chervoneva; Adam C Berger; Edward J Hartsough; Jessie Villanueva; Andrew E Aplin
Journal:  Pigment Cell Melanoma Res       Date:  2019-05-20       Impact factor: 4.693

4.  PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives.

Authors:  Hiroyuki Inuzuka; Jing Liu; Wenyi Wei; Abdol-Hossein Rezaeian
Journal:  Acta Mater Med       Date:  2022-01-21

5.  Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals.

Authors:  Marina Fosso Yatchang; Bini Mathew; Ritesh K Srivastava; Jasim Khan; Suhail Muzaffar; Sixue Zhang; Mousheng Wu; Ling Zhai; Pedro Ruiz; Anupam Agarwal; James R Bostwick; Mark J Suto; Mohammad Athar; Corinne E Augelli-Szafran
Journal:  Bioorg Med Chem Lett       Date:  2022-03-19       Impact factor: 2.940

6.  Bromodomain and Extraterminal (BET) Proteins Regulate Hepatocyte Proliferation in Hepatocyte-Driven Liver Regeneration.

Authors:  Jacquelyn O Russell; Sungjin Ko; Harvinder S Saggi; Sucha Singh; Minakshi Poddar; Donghun Shin; Satdarshan P Monga
Journal:  Am J Pathol       Date:  2018-03-12       Impact factor: 4.307

7.  The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC.

Authors:  Hassen S Wollebo; Anna Bellizzi; Dominique H Cossari; Julian Salkind; Mahmut Safak; Martyn K White
Journal:  J Neurovirol       Date:  2016-03-23       Impact factor: 2.643

8.  Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival.

Authors:  Minji Lee; Farnoosh Tayyari; Dushanthi Pinnaduwage; Jane Bayani; John M S Bartlett; Anna Marie Mulligan; Shelley B Bull; Irene L Andrulis
Journal:  BMC Cancer       Date:  2018-07-20       Impact factor: 4.430

9.  (+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling.

Authors:  Huanhuan Wang; Wenhai Huang; Meihao Liang; Yingying Shi; Chixiao Zhang; Qin Li; Meng Liu; Yikai Shou; Hongping Yin; Xiaozheng Zhu; Xiaoyan Sun; Yu Hu; Zhengrong Shen
Journal:  Cell Biosci       Date:  2018-11-20       Impact factor: 7.133

Review 10.  Epigenetics in Cardiac Fibrosis: Emphasis on Inflammation and Fibroblast Activation.

Authors:  Marina B Felisbino; Timothy A McKinsey
Journal:  JACC Basic Transl Sci       Date:  2018-11-12
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