| Literature DB >> 25288136 |
Enda M Byrne1, Tõnu Esko2,3,4,5, Michael A Nalls6, Marilyn C Cornelis7,8, Andrea Ganna9, Nina Paynter10, Keri L Monda11, Najaf Amin12, Krista Fischer2, Frida Renstrom13, Julius S Ngwa14, Ville Huikari15, Alana Cavadino16, Ilja M Nolte17, Alexander Teumer18, Kai Yu19, Pedro Marques-Vidal20, Rajesh Rawal21, Ani Manichaikul22, Mary K Wojczynski23, Jacqueline M Vink24, Jing Hua Zhao25, George Burlutsky26, Jari Lahti27,28, Vera Mikkilä29,30, Rozenn N Lemaitre31, Joel Eriksson32, Solomon K Musani33, Toshiko Tanaka34, Frank Geller35, Jian'an Luan25, Jennie Hui36,37,38,39, Reedik Mägi2, Maria Dimitriou40, Melissa E Garcia41, Weang-Kee Ho42, Margaret J Wright43, Lynda M Rose10, Patrik Ke Magnusson9, Nancy L Pedersen9, David Couper44, Ben A Oostra45, Albert Hofman12, Mohammad Arfan Ikram12,46,47, Henning W Tiemeier12,48, Andre G Uitterlinden12,49, Frank Ja van Rooij12, Inês Barroso50,51, Ingegerd Johansson52, Luting Xue14, Marika Kaakinen15,53,54, Lili Milani2, Chris Power16, Harold Snieder17, Ronald P Stolk17, Sebastian E Baumeister55, Reiner Biffar56, Fangyi Gu19, François Bastardot57, Zoltán Kutalik58,59,60, David R Jacobs61, Nita G Forouhi25, Evelin Mihailov2, Lars Lind62, Cecilia Lindgren63, Karl Michaëlsson64, Andrew Morris63, Majken Jensen8, Kay-Tee Khaw42, Robert N Luben42, Jie Jin Wang26, Satu Männistö65, Mia-Maria Perälä65, Mika Kähönen66, Terho Lehtimäki67, Jorma Viikari68, Dariush Mozaffarian7,8,69, Kenneth Mukamal70, Bruce M Psaty31,71,72,73, Angela Döring74, Andrew C Heath75, Grant W Montgomery43, Norbert Dahmen76, Teresa Carithers77, Katherine L Tucker78, Luigi Ferrucci34, Heather A Boyd35, Mads Melbye35, Jorien L Treur24, Dan Mellström32, Jouke Jan Hottenga24, Inga Prokopenko63,79, Anke Tönjes80,81, Panos Deloukas50,82,83, Stavroula Kanoni82, Mattias Lorentzon32, Denise K Houston84, Yongmei Liu84, John Danesh42, Asif Rasheed85, Marc A Mason86, Alan B Zonderman87, Lude Franke88, Bruce S Kristal89,90, Juha Karjalainen88, Danielle R Reed91, Harm-Jan Westra88, Michele K Evans86, Danish Saleheen42,85, Tamara B Harris41, George Dedoussis40, Gary Curhan7, Michael Stumvoll80,81, John Beilby36,37,38, Louis R Pasquale7,92, Bjarke Feenstra35, Stefania Bandinelli93, Jose M Ordovas94, Andrew T Chan7,95, Ulrike Peters96, Claes Ohlsson32, Christian Gieger21, Nicholas G Martin43, Melanie Waldenberger97, David S Siscovick31,71, Olli Raitakari30,98, Johan G Eriksson28,99,100, Paul Mitchell26, David J Hunter7,101, Peter Kraft101, Eric B Rimm7,8,69, Dorret I Boomsma24, Ingrid B Borecki23, Ruth Jf Loos25,102,103, Nicholas J Wareham25, Peter Vollenweider57, Neil Caporaso19, Hans Jörgen Grabe104, Marian L Neuhouser105, Bruce Hr Wolffenbuttel106, Frank B Hu7,8,69, Elina Hyppönen16,107,108, Marjo-Riitta Järvelin15,53,54,109,110, L Adrienne Cupples14,111, Paul W Franks8,13,112, Paul M Ridker10, Cornelia M van Duijn12,113, Gerardo Heiss11, Andres Metspalu2, Kari E North11, Erik Ingelsson62,63, Jennifer A Nettleton114, Rob M van Dam115, Daniel I Chasman10.
Abstract
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log10Bayes factor (BF)>5.64) with per-allele effect sizes of 0.03-0.14 cups per day. Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine. Two map to GCKR and MLXIPL genes related to metabolic traits but lacking known roles in coffee consumption. Enhancer and promoter histone marks populate the regions of many confirmed loci and several potential regulatory SNPs are highly correlated with the lead SNP of each. SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smoking initiation, higher adiposity and fasting insulin and glucose but lower blood pressure and favorable lipid, inflammatory and liver enzyme profiles (P<5 × 10(-8)).Our genetic findings among European and African-American adults reinforce the role of caffeine in mediating habitual coffee consumption and may point to molecular mechanisms underlying inter-individual variability in pharmacological and health effects of coffee.Entities:
Mesh：
Substances：
Year: 2014 PMID： 25288136 PMCID： PMC4388784 DOI： 10.1038/mp.2014.107
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992