Literature DB >> 25288088

Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro.

Lizette Grobler1, Marina Chavchich2, Richard K Haynes3, Michael D Edstein2, Anne F Grobler4.   

Abstract

The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability to induce dormancy in Plasmodium falciparum. There was no increase in the activity of artemisone entrapped in Pheroid vesicles against multidrug-resistant P. falciparum lines. Artemisone induced the formation of dormant ring stages similar to dihydroartemisinin. Thus, the Pheroid delivery system neither improved the activity of artemisone nor prevented the induction of dormant rings.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25288088      PMCID： PMC4249507          DOI： 10.1128/AAC.02707-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum.

Authors:  Quinton L Fivelman; Ipemida S Adagu; David C Warhurst
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

2.  Artemisone--a highly active antimalarial drug of the artemisinin class.

Authors:  Richard K Haynes; Burkhard Fugmann; Jörg Stetter; Karl Rieckmann; Hans-Dietrich Heilmann; Ho-Wai Chan; Man-Ki Cheung; Wai-Lun Lam; Ho-Ning Wong; Simon L Croft; Livia Vivas; Lauren Rattray; Lindsay Stewart; Wallace Peters; Brian L Robinson; Michael D Edstein; Barbara Kotecka; Dennis E Kyle; Bernhard Beckermann; Michael Gerisch; Martin Radtke; Gabriele Schmuck; Wolfram Steinke; Ute Wollborn; Karl Schmeer; Axel Römer
Journal:  Angew Chem Int Ed Engl       Date:  2006-03-20       Impact factor: 15.336

3.  Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.

Authors:  M Korsinczky; N Chen; B Kotecka; A Saul; K Rieckmann; Q Cheng
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191

4.  Preparation of beta-artemether liposomes, their HPLC-UV evaluation and relevance for clearing recrudescent parasitaemia in Plasmodium chabaudi malaria-infected mice.

Authors:  B Chimanuka; M Gabriëls; M-R Detaevernier; J A Plaizier-Vercammen
Journal:  J Pharm Biomed Anal       Date:  2002-04-01       Impact factor: 3.935

5.  Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens.

Authors:  M B Hoshen; K Na-Bangchang; W D Stein; H Ginsburg
Journal:  Parasitology       Date:  2000-09       Impact factor: 3.234

6.  Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.

Authors:  L Vivas; L Rattray; L B Stewart; B L Robinson; B Fugmann; R K Haynes; W Peters; S L Croft
Journal:  J Antimicrob Chemother       Date:  2007-03-02       Impact factor: 5.790

Review 7.  Qinghaosu (artemisinin): the price of success.

Authors:  N J White
Journal:  Science       Date:  2008-04-18       Impact factor: 47.728

8.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

9.  First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone.

Authors:  Johannes Nagelschmitz; Barbara Voith; Georg Wensing; Axel Roemer; Burkhard Fugmann; Richard K Haynes; Barbara M Kotecka; Karl H Rieckmann; Michael D Edstein
Journal:  Antimicrob Agents Chemother       Date:  2008-06-16       Impact factor: 5.191

10.  Antimalarial quinolones: synthesis, potency, and mechanistic studies.

Authors:  Rolf W Winter; Jane X Kelly; Martin J Smilkstein; Rozalia Dodean; David Hinrichs; Michael K Riscoe
Journal:  Exp Parasitol       Date:  2007-11-07       Impact factor: 2.011
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  6 in total

1.  The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites.

Authors:  Marina Chavchich; Karin Van Breda; Kerryn Rowcliffe; Thierry T Diagana; Michael D Edstein
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

2.  Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency.

Authors:  Min Zhang; Julio Gallego-Delgado; Cristina Fernandez-Arias; Norman C Waters; Ana Rodriguez; Moriya Tsuji; Ronald C Wek; Victor Nussenzweig; William J Sullivan
Journal:  Cell Host Microbe       Date:  2017-12-13       Impact factor: 21.023

3.  The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites.

Authors:  L Dembele; X Ang; M Chavchich; G M C Bonamy; J J Selva; M Yi-Xiu Lim; C Bodenreider; B K S Yeung; F Nosten; B M Russell; M D Edstein; J Straimer; D A Fidock; T T Diagana; P Bifani
Journal:  Sci Rep       Date:  2017-05-24       Impact factor: 4.379

4.  Locally transmitted malaria in Tawau, Sabah, Malaysia.

Authors:  Vivek J Jayaraj; Dhesi Baharaja; Navindran Gopalakrishnan; Yomain Kaco
Journal:  Malariaworld J       Date:  2017-10-01

5.  Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether.

Authors:  Daniel J Watson; Lizahn Laing; Liezl Gibhard; Ho Ning Wong; Richard K Haynes; Lubbe Wiesner
Journal:  Antimicrob Agents Chemother       Date:  2021-07-16       Impact factor: 5.191

6.  The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside.

Authors:  Liezl Gibhard; Dina Coertzen; Janette Reader; Mariëtte E van der Watt; Lyn-Marie Birkholtz; Ho Ning Wong; Kevin T Batty; Richard K Haynes; Lubbe Wiesner
Journal:  Pharmaceutics       Date:  2021-12-03       Impact factor: 6.321
  6 in total

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