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Literature DB >> 25287933

Renal control of calcium, phosphate, and magnesium homeostasis.

Judith Blaine¹, Michel Chonchol², Moshe Levi².

Abstract

Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels. Renal regulation of these ions occurs through glomerular filtration and tubular reabsorption and/or secretion and is therefore an important determinant of plasma ion concentration. Under physiologic conditions, the whole body balance of calcium, phosphate, and magnesium is maintained by fine adjustments of urinary excretion to equal the net intake. This review discusses how calcium, phosphate, and magnesium are handled by the kidneys.

Entities: Chemical Disease

Keywords: calcium; cell and transport physiology; channel; electrolytes; ion; renal physiology

Mesh：

Substances：

Year: 2014 PMID： 25287933 PMCID： PMC4491294 DOI： 10.2215/CJN.09750913

Source DB: PubMed Journal: Clin J Am Soc Nephrol ISSN： 1555-9041 Impact factor: 8.237

109 in total

1. Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter.

Authors: Andrea Bacconi; Leila V Virkki; Jürg Biber; Heini Murer; Ian C Forster
Journal: Proc Natl Acad Sci U S A Date: 2005-08-19 Impact factor: 11.205

Review 2. Vitamin D deficiency.

Authors: Michael F Holick
Journal: N Engl J Med Date: 2007-07-19 Impact factor: 91.245

Review 3. Recent advances in renal tubular calcium reabsorption.

Authors: Arjen R Mensenkamp; Joost G J Hoenderop; René J M Bindels
Journal: Curr Opin Nephrol Hypertens Date: 2006-09 Impact factor: 2.894

4. Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL.

Authors: W H Wang; M Lu; S C Hebert
Journal: Am J Physiol Date: 1996-07

Review 5. Control of renal calcium, phosphate, electrolyte, and water excretion by the calcium-sensing receptor.

Authors: R Tyler Miller
Journal: Best Pract Res Clin Endocrinol Metab Date: 2013-05-15 Impact factor: 4.690

6. Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+/H+ exchanger regulatory factor-1 complexes.

Authors: Nadine Déliot; Nati Hernando; Zeya Horst-Liu; Serge M Gisler; Paola Capuano; Carsten A Wagner; Desa Bacic; Stephen O'Brien; Jürg Biber; Heini Murer
Journal: Am J Physiol Cell Physiol Date: 2005-03-23 Impact factor: 4.249

7. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi.

Authors: Ricardo Villa-Bellosta; Silvia Ravera; Victor Sorribas; Gerti Stange; Moshe Levi; Heini Murer; Jürg Biber; Ian C Forster
Journal: Am J Physiol Renal Physiol Date: 2008-12-10

8. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene.

Authors: Mariko Ishiguro; Hironori Yamamoto; Masashi Masuda; Mina Kozai; Yuichiro Takei; Sarasa Tanaka; Tadatoshi Sato; Hiroko Segawa; Yutaka Taketani; Hidekazu Arai; Ken-Ichi Miyamoto; Eiji Takeda
Journal: Biochem J Date: 2010-03-15 Impact factor: 3.857

9. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.

Authors: Hiroko Segawa; Akemi Onitsuka; Junya Furutani; Ichiro Kaneko; Fumito Aranami; Natsuki Matsumoto; Yuka Tomoe; Masashi Kuwahata; Mikiko Ito; Mitsuru Matsumoto; Minqi Li; Norio Amizuka; Ken-ichi Miyamoto
Journal: Am J Physiol Renal Physiol Date: 2009-07-01

Review 10. Regulation of phosphate transport in proximal tubules.

Authors: J Biber; N Hernando; I Forster; H Murer
Journal: Pflugers Arch Date: 2008-08-29 Impact factor: 3.657

163 in total

1. Bone metabolism, density, and geometry in postmenopausal women with vitamin D insufficiency: a cross-sectional comparison of the effects of elevated parathyroid levels.

Authors: L L Rødbro; L S Bislev; T Sikjær; L Rejnmark
Journal: Osteoporos Int Date: 2018-06-28 Impact factor: 4.507

2. Calcitriol and FGF-23, but neither PTH nor sclerostin, are associated with calciuria in CKD.

Authors: J Ramalho; E M Petrillo; A P M Takeichi; R M A Moyses; S M Titan
Journal: Int Urol Nephrol Date: 2019-07-31 Impact factor: 2.370

3. Anion Gap as a Determinant of Ionized Fraction of Divalent Cations in Hemodialysis Patients.

Authors: Yusuke Sakaguchi; Takayuki Hamano; Keiichi Kubota; Tatsufumi Oka; Satoshi Yamaguchi; Ayumi Matsumoto; Nobuhiro Hashimoto; Daisuke Mori; Yasue Obi; Isao Matsui; Yoshitaka Isaka
Journal: Clin J Am Soc Nephrol Date: 2017-11-27 Impact factor: 8.237

Renal control of calcium, phosphate, and magnesium homeostasis.

1. Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter.

Review 2. Vitamin D deficiency.

Review 3. Recent advances in renal tubular calcium reabsorption.

4. Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL.

Review 5. Control of renal calcium, phosphate, electrolyte, and water excretion by the calcium-sensing receptor.

6. Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+/H+ exchanger regulatory factor-1 complexes.

7. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi.

8. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene.

9. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.

Review 10. Regulation of phosphate transport in proximal tubules.

1. Bone metabolism, density, and geometry in postmenopausal women with vitamin D insufficiency: a cross-sectional comparison of the effects of elevated parathyroid levels.

2. Calcitriol and FGF-23, but neither PTH nor sclerostin, are associated with calciuria in CKD.

3. Anion Gap as a Determinant of Ionized Fraction of Divalent Cations in Hemodialysis Patients.

4. Intestinal phosphate absorption: The paracellular pathway predominates?

Review 5. Control of phosphate balance by the kidney and intestine.

6. Urinary Phosphorus Excretion: Not What We Have Believed It to Be?

7. Inching toward a Greater Understanding of Genetic Hypercalciuria: The Role of Claudins.

Review 8. Role of renal TRP channels in physiology and pathology.

9. Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial.

Review 10. Phosphate imbalance in patients with heart failure.