OBJECTIVES: To study aluminum (Al), manganese (Mn), and lead (Pb) influence on amyotrophic lateral sclerosis (ALS) development. METHODS: A total of 34 patients (10% of the regional ALS population) and 25 controls of an Italian region were enrolled. Metal concentrations were determined by atomic absorption spectroscopy. RESULTS: Serum Al concentrations in patients and controls were similar and lower than those provided by the Italian Society of Reference Values. No differences were observed in serum Mn concentrations, while, as expected, blood Pb levels were significantly higher in patients with ALS than those in controls. CONCLUSIONS: Results confirmed the association between high Pb blood levels and ALS; on the contrary, Al and Mn did not differ significantly in patients and controls, suggesting that Mn and especially Al may play a less important role in the ALS pathogenesis.
OBJECTIVES: To study aluminum (Al), manganese (Mn), and lead (Pb) influence on amyotrophic lateral sclerosis (ALS) development. METHODS: A total of 34 patients (10% of the regional ALS population) and 25 controls of an Italian region were enrolled. Metal concentrations were determined by atomic absorption spectroscopy. RESULTS: Serum Al concentrations in patients and controls were similar and lower than those provided by the Italian Society of Reference Values. No differences were observed in serum Mn concentrations, while, as expected, blood Pb levels were significantly higher in patients with ALS than those in controls. CONCLUSIONS: Results confirmed the association between high Pb blood levels and ALS; on the contrary, Al and Mn did not differ significantly in patients and controls, suggesting that Mn and especially Al may play a less important role in the ALS pathogenesis.
Authors: Peter E A Ash; Uma Dhawan; Samantha Boudeau; Shuwen Lei; Yari Carlomagno; Mark Knobel; Louloua F A Al Mohanna; Steven R Boomhower; M Christopher Newland; David H Sherr; Benjamin Wolozin Journal: Toxicol Sci Date: 2019-01-01 Impact factor: 4.849
Authors: Tracy L Peters; John D Beard; David M Umbach; Kelli Allen; Jean Keller; Daniela Mariosa; Dale P Sandler; Silke Schmidt; Fang Fang; Weimin Ye; Freya Kamel Journal: Neurotoxicology Date: 2016-04-13 Impact factor: 4.294
Authors: Manouchehr Hessabi; Mohammad H Rahbar; Iuliana Dobrescu; MacKinsey A Bach; Liana Kobylinska; Jan Bressler; Megan L Grove; Katherine A Loveland; Ilinca Mihailescu; Maria Cristina Nedelcu; Mihaela Georgeta Moisescu; Bogdan Mircea Matei; Christien Oktaviani Matei; Florina Rad Journal: Int J Environ Res Public Health Date: 2019-06-28 Impact factor: 3.390
Authors: Susan Peters; Karin Broberg; Valentina Gallo; Michael Levi; Maria Kippler; Paolo Vineis; Jan Veldink; Leonard van den Berg; Lefkos Middleton; Ruth C Travis; Manuela M Bergmann; Domenico Palli; Sara Grioni; Rosario Tumino; Alexis Elbaz; Tim Vlaar; Francesca Mancini; Tilman Kühn; Verena Katzke; Antonio Agudo; Fernando Goñi; Jesús-Humberto Gómez; Miguel Rodríguez-Barranco; Susana Merino; Aurelio Barricarte; Antonia Trichopoulou; Mazda Jenab; Elisabete Weiderpass; Roel Vermeulen Journal: Ann Neurol Date: 2020-11-06 Impact factor: 10.422
Authors: Xiaoke Zeng; Jill Macleod; Colin Berriault; Nathan L DeBono; Victoria H Arrandale; Anne M Harris; Paul A Demers Journal: Scand J Work Environ Health Date: 2021-09-30 Impact factor: 5.024
Authors: Lassi Koski; Cecilia Ronnevi; Elina Berntsson; Sebastian K T S Wärmländer; Per M Roos Journal: Int J Mol Sci Date: 2021-11-11 Impact factor: 5.923
Authors: Angeline S Andrew; Walter G Bradley; Daniel Peipert; Tanya Butt; Kwadwo Amoako; Erik P Pioro; Rup Tandan; John Novak; Adam Quick; K Doug Pugar; Komal Sawlani; Bashar Katirji; Todd A Hayes; Pamela Cazzolli; Jiang Gui; Paul Mehta; D Kevin Horton; Elijah W Stommel Journal: Muscle Nerve Date: 2020-10-18 Impact factor: 3.217