Rachid Tahiri Joutei Hassani1, Hong Liang2, Mohamed El Sanharawi3, Emmanuelle Brasnu1, Sofiene Kallel4, Antoine Labbé5, Christophe Baudouin6. 1. Department of Ophthalmology, 3 Quinze-Vingts National Ophthalmology Hospital, Paris; Center for Clinical Investigations INSERM 503, Quinze-Vingts National Eye Center, Paris. 2. Department of Ophthalmology, 3 Quinze-Vingts National Ophthalmology Hospital, Paris; Center for Clinical Investigations INSERM 503, Quinze-Vingts National Eye Center, Paris; INSERM, U968, Paris, F-75012, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris F-75012; CNRS, UMR_7210, Paris F-75012, France. 3. Department of Ophthalmology, 3 Quinze-Vingts National Ophthalmology Hospital, Paris. 4. Department of Ophthalmology, 3 Quinze-Vingts National Ophthalmology Hospital, Paris; Department of Ophthalmology, Ambroise Paré Hospital, AP-HP, UFR Paris-île de France Ouest, University of Versailles Saint-Quentin-en-Yvelines, Versailles, France. 5. Department of Ophthalmology, 3 Quinze-Vingts National Ophthalmology Hospital, Paris; Center for Clinical Investigations INSERM 503, Quinze-Vingts National Eye Center, Paris; INSERM, U968, Paris, F-75012, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris F-75012; CNRS, UMR_7210, Paris F-75012, France; Department of Ophthalmology, Ambroise Paré Hospital, AP-HP, UFR Paris-île de France Ouest, University of Versailles Saint-Quentin-en-Yvelines, Versailles, France. 6. Department of Ophthalmology, 3 Quinze-Vingts National Ophthalmology Hospital, Paris; Center for Clinical Investigations INSERM 503, Quinze-Vingts National Eye Center, Paris; INSERM, U968, Paris, F-75012, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris F-75012; CNRS, UMR_7210, Paris F-75012, France; Department of Ophthalmology, Ambroise Paré Hospital, AP-HP, UFR Paris-île de France Ouest, University of Versailles Saint-Quentin-en-Yvelines, Versailles, France. Electronic address: cbaudouin@quinze-vingts.fr.
Abstract
PURPOSE: To explore the potential of spectral-domain optical coherence tomography (SD-OCT) using the en-face technology for the imaging of ocular surface diseases and to correlate the findings with in vivo confocal microscopy (IVCM) images. PATIENTS AND METHODS: 113 eyes of 75 subjects with various ocular surface diseases were investigated with the RTVue(®) anterior-segment en face OCT. En face OCT images were compared to B-scan OCT and IVCM images. RESULTS: Patients with corneal dystrophies, corneal deposits, keratitis, pterygium, conjunctivochalasis, or ocular surface squamous neoplasia and patients who underwent lamellar corneal surgeries were included. En-face OCT images showed ocular surface tissue changes that were not discernible using conventional B-scan OCT. Nevertheless, there was a good correlation with IVCM analysis. Compared with IVCM, the major advantages of en-face OCT included easy operation and rapid image acquisition, with minimal operator experience required. In addition, the non-contact method avoided patient discomfort and external pressure on the globe, which was especially useful in patients with corneal dystrophies, ulcers, or corneal abscesses. Although the resolution of en-face OCT was lower than that of IVCM, it allowed useful overall visualization of corneal lesions due to the larger areas analyzed. CONCLUSION: En-face SD-OCT is a novel, valuable tool to assess a wide variety of ocular surface diseases. It can provide additional information and new insight into different ocular surface conditions with no corneal contact.
PURPOSE: To explore the potential of spectral-domain optical coherence tomography (SD-OCT) using the en-face technology for the imaging of ocular surface diseases and to correlate the findings with in vivo confocal microscopy (IVCM) images. PATIENTS AND METHODS: 113 eyes of 75 subjects with various ocular surface diseases were investigated with the RTVue(®) anterior-segment en face OCT. En face OCT images were compared to B-scan OCT and IVCM images. RESULTS:Patients with corneal dystrophies, corneal deposits, keratitis, pterygium, conjunctivochalasis, or ocular surface squamous neoplasia and patients who underwent lamellar corneal surgeries were included. En-face OCT images showed ocular surface tissue changes that were not discernible using conventional B-scan OCT. Nevertheless, there was a good correlation with IVCM analysis. Compared with IVCM, the major advantages of en-face OCT included easy operation and rapid image acquisition, with minimal operator experience required. In addition, the non-contact method avoided patient discomfort and external pressure on the globe, which was especially useful in patients with corneal dystrophies, ulcers, or corneal abscesses. Although the resolution of en-face OCT was lower than that of IVCM, it allowed useful overall visualization of corneal lesions due to the larger areas analyzed. CONCLUSION: En-face SD-OCT is a novel, valuable tool to assess a wide variety of ocular surface diseases. It can provide additional information and new insight into different ocular surface conditions with no corneal contact.
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